1. Warm-Up (1/12) Describe how a cell differentiates during development.
On the piece of white paper from the back, answer the following question.
Name
Date
Period
Describe how a cell differentiates during development.

2. 2E.1c: Programmed cell death (apoptosis) plays a role in the normal development and differentiation.
Illustrative example: Morphogenesis of fingers and toes
4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic enzymes, which are important in intracellular digestion, the recycling of a cell’s organic materials and programmed cell death (apoptosis). Lysosomes carry out intracellular digestion in a variety of ways.
4A.3c: Environmental stimuli can affect gene expression in a mature cell.

3. Differentiation through Death1.
Apoptosis =
programmed cell death used for normal development. 2. 3.

4. Apoptosis: Cell Suicide
Lysosomes are organelles filled with acid and enzymes which digest cellular waste.
Lysosome
nucleus

5. Apoptosis: Cell Suicide
Lysosomes are organelles filled with acid and enzymes which digest cellular waste.
receptor
LYSOSOME
ACTIVATOR PROTEIN
apoptosis
signal P
2nd messenger
Lysosome TF
nucleus

6. Apoptosis: Cell Suicide
Lysosomes are organelles filled with acid and enzymes which digest cellular waste.
receptor
apoptosis
signal P
2nd messenger
Lysosome
nucleus

7. Apoptosis: Cell Suicide
Lysosomes are organelles filled with acid and enzymes which digest cellular waste.
MR. CELL
Lysosome
nucleus

8. Differentiation through Death1.
Cells that are going to die
Apoptosis =
programmed cell death used for normal development. 2. 3.
Cells that did die

9. Critical Thinking Question #1
Discuss this question with your partner and write or represent it. I will call on three people to share their partners’ answers.
Describe how apoptosis plays a role in development.

10. Critical Thinking Question #2
The model below shows a cell with a receptor that is un- activated. Redraw this model and revise it to show how signals from other cells can promote apoptosis.

11. 2E.1c: Programmed cell death (apoptosis) plays a role in the normal development and differentiation.
Illustrative example: Morphogenesis of fingers and toes
4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic enzymes, which are important in intracellular digestion, the recycling of a cell’s organic materials and programmed cell death (apoptosis). Lysosomes carry out intracellular digestion in a variety of ways.
4A.3c: Environmental stimuli can affect gene expression in a mature cell.

12. Illustrative Example: Melanin Production
Environmental stimuli can affect gene expression in a mature cell.
cell membrane
melanin
nucleus
RNA
UV damage
melanin gene

13. Illustrative Example: Melanin Production
Environmental stimuli can affect gene expression in a mature cell.
cell membrane
melanin
nucleus
RNA
UV damage
melanin gene

14. Closure
On the piece of white paper from the back, answer the following question:
Name
Date
Period
How do processes occurring in the nucleus affect the lysosome when a cell undergoes apoptosis?
Scale 1 – 10