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Copyright © 2002 American Medical Association. All rights reserved.

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1 Copyright © 2002 American Medical Association. All rights reserved.
From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20): doi: /jama Figure Legend: AGE indicates advanced glycation endproduct; oxLDL, oxidized low-densitylipoprotein; GSH, glutathione; GSSG, glutathione disulfide; and NADPH, nicotinamide-adeninedinucleotide phosphate. Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.

2 Copyright © 2002 American Medical Association. All rights reserved.
From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20): doi: /jama Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.

3 Copyright © 2002 American Medical Association. All rights reserved.
From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20): doi: /jama Figure Legend: NADPH indicates reduced nicotinamide-adenine dinucleotide phosphate;NADP+, oxidized nicotinamide-adenine dinucleotide phosphate; NAD+, oxidized nicotinamide adenine dinucleotide; and NADH, reduced nicotinamideadenine dinucleotide. Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.

4 Copyright © 2002 American Medical Association. All rights reserved.
From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20): doi: /jama Figure Legend: AR indicates aldose reductase; RAGE, receptor for advanced glycationendproducts; PKC, protein kinase C. Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.

5 Copyright © 2002 American Medical Association. All rights reserved.
From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20): doi: /jama Figure Legend: OXPHOS indicates oxidative phosphorylation; ROI, reactive oxygenintermediate; AGE, advanced glycation endproduct; and NADPH, nicotinamide-adeninedinucleotide phosphate. Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.


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