1. SLEPT Trial Examined Role of Sleep Intervention to Improve Blood Pressure
From ESH 2016 | POS 4C:
A. Power, MD
HRB-Clinical Research Facility Galway, National University of Ireland, Galway, Ireland

2. Overview
Proof-of-concept trial demonstrated improvement in sleep quality and psychosocial health with a simple, low-cost, Internet-based sleep intervention
No improvement in primary outcome of improved blood pressure control in population with mild hypertension at 8 weeks
Potential of benefit in patients with higher baseline blood pressure or with longer follow-up cannot be excluded

3. Overview
Investigator-blinded study randomized 67 community- dwelling adults to Internet-based sleep intervention or no sleep intervention
All participants received standard CV risk factor education
Sleepio, the sleep intervention, consisted of online sleep- hygiene education and a standardized cognitive behavioral therapy (CBT) delivered in weekly sessions over 6-8 weeks by an animated virtual therapist, with automated reminders, and feedback, support, education
Participants had self-reported sleep difficulty, defined as taking >30 minutes to go to sleep or waking up >1 time nightly for ≥3 months

4. Baseline Characteristics in SLEPT Study
Variable
N (%)
Standard care
n=67
Sleep intervention
Demographics
Age, mean (SD), y
58.3 (11.9)
59.7 (9.9)
Female
42 (62.7)
40 (59.7)
Vascular risk factors
Daytime SBP, mean (SD)
141.1 (11.3)
143.0 (11.7)
Daytime DBP, mean (SD)
83.9 (9.5)
86.3 (8.6)
Resting heart rate, mean
70.7 (12.5)
73.5 (10.6)
BMI, mean (SD), kg/m2
27.1 (3.5)
27.0 (4.8)
Dyslipidaemia
23 (34.3)
28 (41.8)
Atrial fibrillation
2 (3.1)
4 (6.2)
Peripheral vascular disease
1 (1.5)
0 (0)
Current smoker
5 (7.5)
3 (4.5)
BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure.

5. Sleep and Psychosocial Outcomes
Variable
Mean (SD)
Standard care (n=67)
Sleep intervention (n=67)
Difference in change
(treatment vs. control)
Week 0
Week 8
Change
Estimate
(95% CI)
p-value
SCI
4.9
5.4
+0.5
(1.7)
4.8
6.2
+1.3
(1.8)
0.8
( )
0.01
ISI
12.0
10.2
1.7
(4.1)
13.0
8.3
4.5
(4.4)
2.8
( )
<0.001
PSQI
9.8
8.4
1.4
(2.6)
9.7
7.2
2.5
(3.1)
1.1
( )
0.04
BDI
7.9
0.5
(3.7)
9.4
6.5
(5.6)
2.0
(0.3, 3.7)
0.02
BAI
6.9
(3.3)
6.3
4.0
2.2
(4.5)
( )
0.047
ASBP, ambulatory systolic blood pressure; ADBP, ambulatory diastolic blood pressure; NT, nighttime.

6. Blood Pressure Outcomes in SLEPT Study
Variable
Mean (SD)
Standard care
(n=67)
Sleep intervention
(n=54)
Difference in change
(treatment vs. control)
mmHg
Week 0
Week 8
Change
Estimate
(95% CI)
p-value
Mean 24-h ASBP
136.8
136.2
0.8
(9.3)
138.0
136.9
0.9
(9.4)
0.1
( )
0.95
Mean 24-h ADBP
82.5
81.2
1.5
(6.6)
83.5
83.1
0.6
(6.0)
-0.9
( )
0.43
Peak daytime SBP
164.2
162.4
2.2
(25.0)
168.8
165.5
2.4
(25.6)
0.2
( )
0.97
Peak daytime DBP
102.9
103.3
-0.1
(15.6)
107.0
107.5
(15.2)
( )
0.94
Peak NT SBP
142.0
140.5
1.8
(18.5)
139.2
140.3
-0.8
(21.3)
-2.6
( )
0.49
Peak NT DBP
86.3
83.3
3.0
(15.7)
84.7
86.2
-1.4 (16.5)
-4.4
( )
0.14
ASBP, ambulatory systolic blood pressure; ADBP, ambulatory diastolic blood pressure; NT, nighttime.

7. SLEPT Trial Examined Role of Sleep Intervention to Improve Blood Pressure
From ESH 2016 | POS 4C:
A. Power, MD
HRB-Clinical Research Facility Galway, National University of Ireland, Galway, Ireland