1. Advanced maternal age and risk of non-chromosomal anomalies: data from a tertiary referral hospital in Turkey
NADİYE KÖROĞLU
SBÜ KANUNİ SULTAN SULEYMAN TRAINING AND RESEARCH HOSPİTAL

2. Introduction
Congenital anomalies are among the most important causes of fetal and neonatal mortality and morbidity during childhood
Major congenital anomalies are considered as those structural defects that are associated with a high incidence of mortality and morbidity, diagnosed prenatally or in the first year of life.

3. Purpose
The relationship between advanced maternal age (AMA) and aneuploidy has been clearly demonstrated, however, it is not yet clear whether there is a similar relationship between advanced maternal age and nonchromosomal congenital anomalies (NCM) .
Whether advanced maternal age is a risk factor for non- chromosomal major congenital anomalies involving various organ systems using data from a referral centre in Turkey.

4. Materials and Method
387 women of years of age who underwent fetal karyotype testing due to positive prenatal test results or advanced maternal age included in the study (September March 2015).
Fetuses with chromosomal anomalies were excluded from the study.
The relationship between non-chromosomal anomalies and maternal age of <35 or ≥35 (AMA) was studied.

5. Variable
Age≤34
(n=316)
AMA
(n=71) P
value
Mean Maternal age
26,9± 3,9
37,5± 2,92
<0,001
Gravida
2,12± 1,23
3,38± 1,70
0,000
Parity
0,69± 0,87
1,70± 1,38
Presence of consanginous Marriage
27,85%
25,58%
0,019
Diagnostic test perf AS
Cordocentesis
58,23%
21,2%
54,93%
28,17%
0,123
Anomaly type
CNS
Multiple
Cardiac
Skeletal
Urogenital
Gastrointestin
Other
31,3%
24,05%
15,82%
14,87%
6,96%
6,01%
0,95%
26,76%
14,08%
25,35%
12,68%
7,04%
11,27%
2,82%

6. Variables
Age≤34 (n=316)
AMA
P value
CNS Anomalies
Anencephalus
Spina bifida
Hydrocephalus
Encepholocel
Holoprozencep
Other
23,13%
31,34%
19,40%
13,43%
2,99%
9,86%
16%
28%
32%
12% 8% 4%
O,501
Cardiac anomalies
Hipoplastic left
Aort coarctatio
VSD
VSD+ASD
Fallot tetrology
Conotruncal an
2,82%
30,9%
8,45%
19,72%
5,63%
9,52%
4,76%
47,62%
14,29%
0,275
Gastrointestinal anomalies
Present
Absent
11,71%
88,29%
7,04%
92,96%
0,177
Urogenital anomalies
13,61%
86,39%
14,08%
85,92%
0,522
Musculoskeletal anomalies
27,22%
72,78%
16,90%
83,10%
0,046
Multiple anomalies
29,75%
70,25%
25,35%
74,65%
0,280

7. Conclusion
In this study we found that the risk of muskuloskeletal system anomalies decreased with advancing maternal age.
No other organ system anomalies were found to be associated with an increased or decreased risk with advancing maternal age.
No significant difference could be detected in the incidence of major congenital anomalies of other organ systems between those under the age of 35 and those equal to or over the age of 35

8. The incidence of non-chromosomal anomalies does not increase in fetuses of pregnant women over the age of 35, in contrast to chromosomal anomalies.
Women can be reassured that advanced maternal age is not associated with an increased risk of NCA.

9. THANK YOU…