1. Inflammation

7. Inflammatory cytokines
Plasma derived
Bradykinin C3
C5a
Factor XII (Hageman Factor).
Membrane attack complex
Plasmin
Thrombin
Cell derived
Lysosome granules
Histamine
IFN-γ
Leukotriene B4
Nitric oxide
Prostaglandins
TNF-α and IL-1

9. Yacoubian S and Serhan CN (2007) New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases Nat Clin Pract Rheumatol 3: 570–579 doi: /ncprheum0616

10. Albini and Sporn Nature Reviews Cancer 7, 139–147 (February 2007) | doi:10.1038/nrc2067

11. Wound healing Functional aspect Structural aspect Three phases
stop blood loss
restore function
prevent infection
Structural aspect
restoring both cells and their protein matrix
Three phases
Inflammatory phase
proliferative/repair pahse
remodeling/maturation phase

12. Inflammatory phase

13. Proliferative phase

14. Remodeling phase

16. Chronic inflammation - Granuloma

17. Foreign body reaction begins as wound healing
accumulation of exudate
infiltration of inflammatory cells
formation of granulation tissue
persistent presence of a biomedical implant inhibits full healing
Histological findings
formation of foreign body giant cells
encapsulation of the foreign object
chronic inflammation
Nonspecific immune reaction

18. Foreign body reaction Giant cell Encapsulation
Products of macrophage fusion
Hallmark of the foreign body reaction
Secrete degradative agents: superoxides and free radicals
Encapsulation
Firm, avascular collagen shell deposited around a foreign body
Isolating foreign body from the host tissues

19. Artificial Skin

21. Immune privilege

26. Take home message Four symptoms and signs of inflammation
Three stages of wound healing and foreign body reaction
Immune privilege