1. Risk of Otitis Media from modifiable exposures in the Danish national birth cohort
By: Asbjørn Kørvel-Hanquist /KU Anders Koch /SSI Sjurdur F. Olsen /SSI Jørgen Lous /SDU Janni Niclasen /KU Jesper Dammeyer /KU Preben Homøe /KU

2. Disclosure
Financial support:

3. and Social inheritance Prenatal risk attribution
Nævne kværner og casselbach studierne med 50% genetisk homogenisitet

4. 18th month/7 years post partum
Material and method
The Danish National Birth Cohort (DNBC)
Data collected from 1996 to 2004
from more than 100,000 pregnancies
2nd trimester
3rd trimester
18th month/7 years post partum

5. Results
Odds-ratio of achieving ≥ 1 episodes of otitis media at the age of 6 months

6. Results

7. Results

8. Results
Antibiotics in Pregnancy Increase Children’s Risk of Otitis Media and Ventilation Tubes
J Pediatr Jan 11. Pedersen TM, Stokholm J, Thorsen J, Mora-Jensen AC, Bisgaard H.

9. Results

10. Results

11. 5
Results

12. Results

13. Results

14. Strengths and weaknesses
Strengths: -Large size material (N=25,419)
-Prospective data collection
Weaknesses: -Parent-reported disease outcome
-Participation bias
-Does not differentiate between different kinds of otitis media

15. Conclusions
We found an association between maternal use of antibiotics during pregnancy and childhood otitis media
The association seems stronger for consumption of antibiotics during the 2nd trimester

16. Thank you for your time