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Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return.

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Presentation on theme: "Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return."— Presentation transcript:

1 Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return from military deployment  Mirjam van Zuiden, Annemieke Kavelaars, Eric Vermetten, Miranda Olff, Elbert Geuze, Cobi Heijnen  Psychoneuroendocrinology  Volume 51, Pages (January 2015) DOI: /j.psyneuen Copyright © 2014 Elsevier Ltd Terms and Conditions

2 Figure 1 Dexamethasone (DEX) sensitivity of T-cell proliferation of participants with high levels of depressive symptoms (▴), participants with high levels of PTSD symptoms (■) and participants with low PTSD and depressive symptom levels (●) six months after deployment. (A) Area under the curve for relative inhibition of T-cell proliferation by 0–1000nM DEX; (B) IC50 for inhibition of T-cell proliferation by 0–1000nM DEX. Means and SEMs are presented. T0=pre-deployment, T1=1 month post-deployment, T6=6 months post-deployment. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2014 Elsevier Ltd Terms and Conditions

3 Figure 2 Dexamethasone (DEX) sensitivity of TNF-α production of participants with high levels of fatigue (■) and participants with low levels of fatigue (●) six months after deployment. (A) Area under the curve for relative inhibition of TNF-α production by 0–1000nM DEX; (B) IC50 for inhibition of TNF-α production by 0–1000nM DEX. Means and SEMs are presented. T0=pre-deployment, T1=1 month post-deployment, T6=6 months post-deployment. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2014 Elsevier Ltd Terms and Conditions

4 Supplementary Fig. 1 Dose–response curve for relative inhibition of T-cell proliferation by 0–1000nM dexamethasone of participants with high levels of depressive symptoms (▴), participants with high levels of PTSD symptoms (■) and participants with low PTSD and depressive symptom levels (●) six months after deployment. Means and SEMs are presented. T0=pre-deployment, T1=1 month post-deployment, T6=6 months post-deployment. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2014 Elsevier Ltd Terms and Conditions

5 Supplementary Fig. 2 Dose–response curve for relative inhibition of TNF-α production by 0–1000nM dexamethasone of participants with high levels of fatigue symptoms (■) and participants with low levels of fatigue (●) six months after deployment. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2014 Elsevier Ltd Terms and Conditions

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