1. Patient-first Approach for Engagement and Recruitment
David Hou
Taiwan / USA
QuintilesIMS, Singapore

2. There must be a better way …
Why is a digital and
patient-first approach better?
What are the benefits for the
patients, investigators and sites?
© 2016 QuintilesIMS. All rights reserved.

3. Digital landscape: Users by country
90%
Internet Users: 45.3 million
Total Population: 50.4 million
- Let’s first understand what has enabled our patients to become more connected and informed …
Source: Jan-2016; ITU, InternetWorldStats, CIA, Nat’l govt. ministries and industry bodies; UN, US Census Bureau
© 2016 QuintilesIMS. All rights reserved.

4. Digital landscape: Time spent online
Access through Laptop / Desktop
Access through Mobile Device
- Share of web page views: 6% increase on Laptop/desktop and a 12% decrease on mobile
Source: GlobalWebIndex, Q4 2015, Based on surveyed users aged 16 – 64.
© 2016 QuintilesIMS. All rights reserved.

5. Digital landscape: How users access?
Mobile Phones
of adult pop. 98 %
all types 83
smartphone
Computers
of adult pop. 68 %
laptop or
desktop 15
tablets
- How are users accessing digital information and communicating
Other Devices
of adult pop. 6 %
streaming
television 2
wearable
technology
Source: Google Customer Barometer 2015, User Questionnaires.
© 2016 QuintilesIMS. All rights reserved.

6. Digital landscape: What users are doing?
Social Media &
Entertainment
of total pop. 76 % 38
million
active users
Communication
of total pop.
114 % 57
mobile
connections
million
- approx. 25 million gamers / over 30% spend more than 1-hour per day
- 78% of the total population searched for product or service online within the past 30-days
- Internet usage (desktop and mobile combined, ~5 hours per day) exceeds the time spent watching TV (~2 hours per day)
Search/Shopping
of total pop. 78 % 39
searched
online
million
Source: Facebook Q1 2016; Tencent Q3 2015; Vkontakte Q3 2015; LiveInternet.ru Q1 2016; GSMA Intelligence Q4 2015; UN, US Census Bureau for population data; GlobalWebIndex, Q4 2015, Based on surveyed users aged 16 – 64.
© 2016 QuintilesIMS. All rights reserved.

7. Digital landscape: What users are doing?
Social Media &
Entertainment
of total pop. 42 % 53
million
active users
What does this tell us?
How does it change our perception of patients?
Communication
of total pop.
137 %
173
mobile
connections
million
Patients are now more empowered and have more access to information than ever before …
… WE have become “digital” consumers of information … we have become “Digital Patients”
Search/Shopping
of total pop. 65 % 75
searched
online
million
Source: Facebook Q1 2016; Tencent Q3 2015; Vkontakte Q3 2015; LiveInternet.ru Q1 2016; GSMA Intelligence Q4 2015; UN, US Census Bureau for population data; GlobalWebIndex, Q4 2015, Based on surveyed users aged 16 – 64.
© 2016 QuintilesIMS. All rights reserved.

8. Digital landscape: What users are doing?
Social Media &
Entertainment
of total pop. 42 % 53
million
active users
Digital Shopper
Communication
of total pop.
137 %
173
mobile
connections
million
Digital Traveler
Patients are now more empowered and have more access to information than ever before …
… WE have become “digital” consumers of information … we have become “Digital Patients”
Search/Shopping
of total pop. 65 % 75
searched
online
million
Digital Patient
Source: Facebook Q1 2016; Tencent Q3 2015; Vkontakte Q3 2015; LiveInternet.ru Q1 2016; GSMA Intelligence Q4 2015; UN, US Census Bureau for population data; GlobalWebIndex, Q4 2015, Based on surveyed users aged 16 – 64.
© 2016 QuintilesIMS. All rights reserved.

9. Impetus for change: A better way …
Social Media &
Entertainment
of total pop. 42 % 53
million
active users
We consume, share and search for information differently
We now must engage and identify our patients differently
Embrace a patient-first and digital approach to clinical trials
Communication
of total pop.
137 %
173
mobile
connections
million
Patients are now more empowered and have more access to information than ever before …
… WE have become “digital” consumers of information … we have become “Digital Patients”
Search/Shopping
of total pop. 65 % 75
searched
online
million
Digital Patient
Source: Facebook Q1 2016; Tencent Q3 2015; Vkontakte Q3 2015; LiveInternet.ru Q1 2016; GSMA Intelligence Q4 2015; UN, US Census Bureau for population data; GlobalWebIndex, Q4 2015, Based on surveyed users aged 16 – 64.
© 2016 QuintilesIMS. All rights reserved.

10. Digital patient: Path to care …
41%
26%
18%
Start …
Begins
ONSET OF SYMPTOMS
PHYSICIAN OFFICE VISIT
… Patients will even ask for medications by name
Upward trend by patients when searching for information about their health shows that the first step is to search online
Increasingly, patients bring a preliminary diagnosis …
41 % symptoms
26 % options
18 % specialists
Patients are now more empowered and have more access to information than ever before …
… WE have become “digital” consumers of information … we have become “Digital Patients”
55%
40%
36%
RETURNING TO
ONLINE SEARCH
After office visit, online search continues to validate initial diagnoses …
55 % prescriptions
40 % alternatives
36 % equivalents
Source: Makovksy Health and Kelton, Feb-2015
© 2016 QuintilesIMS. All rights reserved.

11. Digital patient: Path to care …
… Continues
MONITORING, KEEPING SCORE, DIGITAL HEALTH
Patients are more empowered by apps and wearables
Personal health monitoring
Collaborative care with physician and other patients
ENGAGING IN THEIR OWN CARE
Patients are now more empowered and have more access to information than ever before …
… WE have become “digital” consumers of information … we have become “Digital Patients”
Mental health
83%
Gastrointestinal
79%
78%
Obesity
75%
Pulmonary
73%
Cardiovascular
Digital Patient
Research diagnosis and prescription from the doctor
Search for alternative treatments or care
Engage with patient groups
Source: Makovksy Health and Kelton, Feb-2015
© 2016 QuintilesIMS. All rights reserved.

12. Adopting a Patient-first approach …
Understanding the patient beyond the eligibility criteria
Right message,
right time and
right method
Patient
Persona
Omni-channel
Outreach
Digital Patient
Patients are now more empowered and have more access to information than ever before …
… WE have become “digital” consumers of information … we have become “Digital Patients”
Patient
Champion
Pathways
To Care
Listen, adjust, respond and predict their needs
Explore all pathways to care, beyond sites
© 2016 QuintilesIMS. All rights reserved.

13. Case study: Patient-first approach …
Increase
Recruitment
Rate
- Case study from a single country in Southeast Asia …
- The patient first approach enabled by a digital strategy helped to get the study back on track …
More Potential Patients
per week
Greater Engagement, Faster Recruitment
© 2016 QuintilesIMS. All rights reserved.

14. Who has the first question?
Coming together is the beginning,
staying together is progress and
working together is success.
-- Henry Ford