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Charles J. Glueck, M. D. , Joel Pranikoff, M. D. , Dawit Aregawi, M. D

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Presentation on theme: "Charles J. Glueck, M. D. , Joel Pranikoff, M. D. , Dawit Aregawi, M. D"— Presentation transcript:

1 Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome 
Charles J. Glueck, M.D., Joel Pranikoff, M.D., Dawit Aregawi, M.D., Ping Wang, Ph.D.  Fertility and Sterility  Volume 89, Issue 3, Pages (March 2008) DOI: /j.fertnstert Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Gestational diabetes in 47 nondiabetic women with PCOS who had 64 live-birth pregnancies without metformin and subsequently had 50 live-birth pregnancies on metformin. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Distribution of GD in 64 pregnancies in 47 women with PCOS before metformin, and in 50 pregnancies in the same 47 women, who were on metformin during subsequent pregnancies. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Median and interquartile range body weight (kg) at pretreatment; preconception baseline; at the last preconception visit on metformin; and during the first, second, and third trimesters. Paired Wilcoxon tests of difference were used. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

5 Figure 4 Median and interquartile range fasting serum insulin (μU/mL) at pretreatment; preconception baseline; at the last preconception visit on metformin; and during the first, second, and third trimesters. Paired Wilcoxon tests of difference were used. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

6 Figure 5 Median HOMA IR at pretreatment; preconception baseline; at the last preconception visit on metformin; and during the first, second, and third trimesters. Paired Wilcoxon tests of difference were used. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions


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