1. Osteogenesis Imperfecta
Annie Le
University of California, Merced

2. Remember…? Calcium is very important for the body
2% Reduced fat milk: 70% of calcium.
Calcium and Vitamin D
Have not been clear that calcium is responsible for healthier bones.

3. Calcium Studies… Twins were being studied.
One pair of twin: 1000mg of calcium daily
The other pair: other supplement
Results?

4. Osteogenesis Imperfecta
OI for short.
“Imperfect bones at the beginning of time”
Not exactly the same as Osteoporosis
Poor Bone density
Genetically carried
Triggered by missing Collagen protein – like a puzzle
COL1A1 and COL1A2

5. Type 4 correlates of type 1 and 2 in higher severity
Types of OI
Type 1 is mild
Brittle teeth
Normal stature
Weak muscles
Loose joints
Type 2 and 3 are severe
Several fractures
Bone deformities
Poor posture
Underdeveloped lungs
Type 4 correlates of type 1 and 2 in higher severity

6. Newly Discovered Types of OI
Intricate mesh like formation when viewed under the microscope.
Type 6
Fish scale like bone features

7. Things to think about when handling with a child diagnosed with OI
High consumption in calcium and vitamin D.
Children with OI are prone to fractures.
Transportation: car seats, strollers…
Bathing
Clothing
Going to school

8. To parents, it is important…
To know that other parents who have children with OI are normally raised like any other child.
More attention, care and love
are involved.
Go seek genetic counseling.
To understand that it is not
your wrongdoing.

9. Any Questions?