1. Imaging Techniques Used to Study Biological Systems
Andy Evans
RISE Associate
Drew University

2. Me Academic B.S. Georgia Tech Ph. D. University of Georgia
Post Docs (1) Centre d’Études Nucléaires Grenoble
(2) University of Western Ontario
Industry
8 years Scientific Instruments (NMR, ESR)
28 Years Pharmaceuticals (Berlex, Schering-Plough, Merck)
Joined RISE December 2012

3. Imaging in Biology and Medicine
From Kerlopian, et al., BMC Systems Biology, 2008, 2, 74 3

4. Filtered Back Projection (128 directions)
Xray (CT) Imaging
Filtered Back Projection (128 directions) 4

5. Full Contrasted Head Scan by CT
30 Seconds!!!
Department of Radiology, Uppsala University Hospital. Uploaded by Mikael Häggström 5

6. NMR and MRI Instrumentation6

7. Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI)
NMR Spectra
Organic Molecule
Water 7

8. How does MRI Work? Magnetic Field = B0 Empty NMR Tube
B = B0 + G/2
B = B0 - G/2
Empty NMR Tube
Capillary Tubes of H2O

9. Brain MRI

10. Brain MRI

11. Brain Tumor

12. Neurological MRI

13. AIDS

14. Sports Injuries

15. Spatial Localization of Brain Activity
Functional MRI
Spatial Localization of Brain Activity

16. Mouse MRI
Coronal
Axial
Sagittal

17. MRI Study of Tablet Dissolution17

18. Possible Projects
Neurological Imaging – fMRI/CT studies of brain response to external stimulus
Neurological Imaging – fMRI/CT studies of disease states (epilepsy, Tourette’s, schizophrenia, etc.)
Neurological Imaging – Structural MRI/CT studies of Alzheimer’s, Parkinson’s, etc.
Anatomical images – Sports injuries, tumor growth or regression, cardiac imaging
Anatomical images – Delineation of vascular structure (Diffusion Tensor Imaging)
Energy – MRI studies of fluid flow through geological formations (Fracking)
Archeological – CT’s of mummies, Ötzi, Antikythera Mechanism
Animal Imaging – Drug discovery, Veterinary applications
Tablet dissolution – Follow water front penetration to detect problem structures in pharmaceutical formulation 18