1. Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology
Lu Jiao 1, 2 ;Duan Xuefeng 1 ;Zhao Wenming 1 ;Wang Jing 1, 2 ;Wang Haoyu 3, 1 ;Zhou Kai 1 ;Fang Min 1, 4 ;
1 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing , China. ; 2 University of Chinese Academy of Sciences, Beijing, China ; 3 Institute of Health Sciences, Anhui University, Hefei, China ; 4 International College, University of Chinese Academy of Sciences, Beijing, China ;
Figure 1. Young and aged mice exhibited different morbidity and mortality post PR8 infection. Young and aged B6 mice were infected i.n. with pfu of PR8 virus. Weight loss A, survival B and viral titers C of infected mice were monitored. D weight loss and survival of the mice after infected with pfu of PR8 virus. E weight loss of the mice when the young mice were infected pfu of PR8 virus, while the aged mice were infected with 1.7#cod#x000D7;10 3 PR8 virus. Data are from at least three independent experiments with more than 3 mice per group in each experiment. Data points indicate means#cod#x000B1;SD. #cod#x0002A; p 0.05,#cod#x0002A;#cod#x0002A; p 0.01, #cod#x0002A;#cod#x0002A;#cod#x0002A; p
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