1. Volume 78, Pages 15-22 (September 2015)
Porous gelatin/tricalcium phosphate/genipin composites containing lumbrokinase for bone repair 
Yuan-Tsung Fu, Shi-Yuan Sheu, Yueh-Sheng Chen, Kuo-Yu Chen, Chun-Hsu Yao 
Bone 
Volume 78, Pages (September 2015)
DOI: /j.bone
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Fig. 1
Effect of lumbrokinase on cell viability of osteoblasts, as determined by MTT assay (*p<0.05, **p<0.01 and ***p<0.001 vs. control).
Bone  , 15-22DOI: ( /j.bone )
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3. Fig. 2
Effect of lumbrokinase on total ALP activity (*p<0.05, **p<0.01 and ***p<0.001 vs. control).
Bone  , 15-22DOI: ( /j.bone )
Copyright © 2015 Elsevier Inc. Terms and Conditions

4. Fig. 3
Effect of lumbrokinase on (A) matrix calcium deposition and (B) the numbers of total calcified nodules formed in the osteoblast cultures at various concentrations of lumbrokinase, as determined by von Kossa stain (*p<0.05 and ***p<0.001 vs. control).
Bone  , 15-22DOI: ( /j.bone )
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5. Fig. 4
Effect of lumbrokinase on the expression of osteogenic-related proteins, as determined using Western blot analysis. γ-Tubulin was used as a loading control.
Bone  , 15-22DOI: ( /j.bone )
Copyright © 2015 Elsevier Inc. Terms and Conditions

6. Fig. 5
Effect of lumbrokinase on the migration of osteoblasts, as determined using wound-healing assay. (A) Photomicrographs of cell migration were obtained at 2days after wounding. (B) The migration ratio after wounding was quantified (***p<0.001 vs. control).
Bone  , 15-22DOI: ( /j.bone )
Copyright © 2015 Elsevier Inc. Terms and Conditions

7. Fig. 6
Effect of lumbrokinase on total TRAP activity (*p<0.05 and **p<0.01 vs. control).
Bone  , 15-22DOI: ( /j.bone )
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8. Fig. 7
Bioluminescence images. (A) IVIS images of bioluminescent GGT and GGTLK composites at 4 and 8weeks postimplantation into rat calvarial defects. (B) Quantitative analysis of bioluminescence images. The intensity of luminescence signal was measured using the ROI settings of the Living Image software. (*p<0.05 and **p<0.01).
Bone  , 15-22DOI: ( /j.bone )
Copyright © 2015 Elsevier Inc. Terms and Conditions

9. Fig. 8
(A) Micro-CT images of rat calvarial bone-covered implant obtained 4 and 8weeks postimplantation of GGT and GGTLK composites (HB=host bone, NB=new bone). The dotted circles indicate the original defects. (B) Quantitative micro-CT analysis of newly-formed bone in rat calvaria defects (*p<0.05).
Bone  , 15-22DOI: ( /j.bone )
Copyright © 2015 Elsevier Inc. Terms and Conditions

10. Bone  , 15-22DOI: ( /j.bone )
Copyright © 2015 Elsevier Inc. Terms and Conditions