1. Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men Amir Tirosh, M.D., Ph.D.,Iris Shai, R.D., Ph.D., Dorit Tekes-Manova, M.D., Eran Israeli, M.D., David Pereg, M.D., Tzippora Shochat, M.Sc., Ilan Kochba, M.D., and Assaf Rudich, M.D., Ph.D., for the Israeli Diabetes Research Group
N Engl J Med 2005;353:

2. Background Normal fasting plasma glucose
Revised by American Diabetes Association
Impaired fasting plasma glucose
100~109 mg/dl (5.55~6.05 mmol/L)
Increased risk for diabetes
Elevated fasting plasma glucose within normal range
Risk factor?

3. Aim fasting plasma glucose levels
identify young, healthy, normoglycemic persons
increased risk for type 2 diabetes?

4. Methods The Melany study Inclusion and exclusion criteria
Israel Defense Forces Staff Periodic Exam
Inclusion and exclusion criteria
1992~2004
13163 men with fasting plasma glucose<100 mg/dl
Excluded:
type 1 or 2 diabetes, women,

5. Result

10. Conclusion
Higher fasting plasma glucose levels within the normoglycemic range
independent risk factor for type 2 diabetes among young men.
BMI and triglyceride levels
identify healthy men at increased risk for diabetes.