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Volume 115, Issue 6, Pages (June 1999)

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Presentation on theme: "Volume 115, Issue 6, Pages (June 1999)"— Presentation transcript:

1 Volume 115, Issue 6, Pages 1553-1562 (June 1999)
Respiratory Muscle Function and Hypoxic Ventilatory Control in Patients With Type I Diabetes  Mancini Marco , MD, Filippelli Mario , MD, Seghieri Giuseppe , MD, Iandelli Iacopo , MD, Innocenti Fabio , MD, Duranti Roberto , MD, Scano Giorgio , MD, FCCP  CHEST  Volume 115, Issue 6, Pages (June 1999) DOI: /chest Copyright © 1999 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Maximal Pessn and Pdisn in the eight diabetic patients.
CHEST  , DOI: ( /chest ) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Average breathing pattern of patients and control subjects. Ascendant limb is the ratio of Vt to Ti. Descendant limb is the ratio of expiratory Vt to Te. Ti + Te = Ttot; 1/Ttot × 60 = Rf. Dashed line represents control subjects; continuous line, diabetic patients. CHEST  , DOI: ( /chest ) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Relationships of e and Pessw(%Pessn) vs Sao2 during progressive hypoxia. Individual regression lines for both patients and normal subjects are shown. CHEST  , DOI: ( /chest ) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Plot of Pessw vs Vt during hypoxic rebreathing. Area depicts the range of the response in the normal control group. Individual regression lines for patients are shown. CHEST  , DOI: ( /chest ) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Plot of swings in Pes vs swings in Pg during progressive hypoxia in patients. Open symbols represent values at end expiration; closed symbols, values at end inspiration. Circles indicate 95% Sao2; squares, 80%; triangles, 72%. At 95% Sao2, the increase in inspiratory Pes was associated with an increase in Pg such that the line joining the end-expiratory point to the end-inspiratory point had a positive slope representing the combined action of the diaphragm and the rib cage inspiratory muscles. During progressive hypoxic stimulation, the end-expiratory point shifted to a greater Pg, indicating expiratory muscle recruitment. CHEST  , DOI: ( /chest ) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

7 Figure 6 Plot of swings in Pes vs swings in Pg during progressive hypoxia in control subjects. Average data are shown. See Figure 5 legend for explanation of the figure and the symbols used. CHEST  , DOI: ( /chest ) Copyright © 1999 The American College of Chest Physicians Terms and Conditions


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