1. Calming the atopic dermatitis flare cycle with Protopic®
VO: Atopic dermatitis is a disease of both skin barrier dysfunction and immune system hyperactivity.1,2
Super:
Danby and Cork, Journal of Clinical Dermatology. 2010, 1(2):33-46
Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21
VO: The stratum corneum can be thought of as a ‘brick wall’. Corneocytes are the bricks. Intercellular lipids acts as cement, while corneodesmosomes serve as iron rods embedded within the cement to stabilise the structure.
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2. VO: In normal skin, the stratum corneum serves as a protection from irritants and allergens in the environment.
VO: In patients with atopic dermatitis, the stratum corneum is disrupted,2...
Super:
Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21
VO: …allowing irritants and allergens from the environment…
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3. 翻译： 翻译： 翻译： VO: …to easily penetrate.2 Super:
Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21
VO: Allergen penetration in turn…
Super:
VO: …leads to the development of an allergic response and inflammation.3
Super:
Cork M et al., Journal of Investigative Dermatology (2009) 129, 1892–1908
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4. AD Skin
VO: As well as having an increased susceptibility to allergen penetration, a defective skin barrier is also responsible for increased trans-epidermal water loss, leading to dry skin.5
Super:
Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):
VO: In a recent study of quiescent AD patients, Protopic® has been shown to decrease trans-epidermal water loss significantly. Following treatment with Protopic®, trans-epidermal water loss improved significantly from baseline, whereas trans-epidermal water loss increased following betamethasone valerate cream treatment.6
Super:
Danby et al., British Journal of Dermatology. 2014, 170:
VO: This is what AD skin looks like…
Super:
Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):
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5. AD Skin treated with TCS and emollients
AD Skin treated with Protopic and emollients
VO: A multifactorial disease requires a multifactorial approach. Atopic dermatitis treatment strategies should target both skin barrier dysfunction as well as the immune system response and inflammation.
VO: TCS can work on the inflammation, and emollients help to protect the skin from the top. But long-term TCS use causes thinning of the epidermal wall, increasing trans-epidermal water loss.5,6
Super:
Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):
Danby et al., British Journal of Dermatology 2014.
VO: By using Protopic® and emollients together as a long-term treatment option, Protopic® works to decrease the inflammation to the same degree as with mid-potency steroids, but also supports the skin barrier. Protopic® has also been shown to significantly increase lipid lamellae in the intercellular space compared to mometasone furoate, thereby reducing trans-epidermal water loss.5
Super:
Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):
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6. TCS
TCS
VO: Steriods are effective for the short term. But long-term use of topical corticosteroids as treatment for AD is not ideal as it can weaken the skin barrier, allowing allergens to penetrate and thereby perpetuating the flare cycle.6
Super:
Danby et al., British Journal of Dermatology 2014.
VO: If you switch to Protopic® after a week of TCS treatment and to use Protopic® as a first choice for the treatment of the early signs of recurring flares, you will reduce the TCS usage in the long term.
VO: Protopic® decreases trans-epidermal water loss, increases lipid lamellae and supports the skin barrier.5,6 Super:
Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):
Danby et al., British Journal of Dermatology. 2014, 170:
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7. 翻译： 翻译： 翻译： VO: …use Protopic® as a first switch after TCS …
VO: Protopic® also acts on inflammation and allows the skin to protect against external triggers, preventing or minimising recurring flares.7,8,9
Super:
Hanifin et al., Journal of the American Academy of Dermatology Aug, 53(2 Suppl. 2):S186-94
Reitamo et al., Journal of Allergy and Clinical Immunology Mar, 109:547–555
Nakagawa, Clinical Drug Investigation. 2006, 26(5):235–246
VO: …use Protopic® as a first switch after TCS …
VO: Protopic® calms the flare cycle and brings control to long-term AD treatment.7,10 For a holistic and effective treatment approach…
Super:
Hanifin et al., Journal of the American Academy of Dermatology Aug, 53(2 Suppl. 2):S186-94
Kapp et al., Journal of Dermatological Treatment. 2003, 14(Suppl. 1):5-16
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8. Protopic® calms the flare cycle.
Protopic® supports the repair of the skin barrier and reduces inflammation.
Protopic® brings control to long-term AD treatment.
VO: Protopic® calms the flare cycle.3,11
Protopic® supports the repair of the skin barrier and reduces inflammation.7
Protopic® brings control to long-term AD treatment.3,11
Super:
3. Kapp et al., Journal of Dermatological Treatment. 2003, 14(Suppl. 1):5-16
11. Hanifin et al., Journal of the American Academy of Dermatology Aug, 53(2 Suppl. 2):S
TCS
VO: …and as a first choice of treatment with early signs of recurring flares.
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9. References:
Danby and Cork, Journal of Clinical Dermatology. 2010, 1(2):33-46
Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21
Cork M et al., Journal of Investigative Dermatology (2009) 129, 1892–1908
Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):
Danby et al., British Journal of Dermatology. 2014, 170:
Hanifin et al., Journal of the American Academy of Dermatology Aug, 53(2 Suppl. 2):S186-94
Reitamo et al., Journal of Allergy and Clinical Immunology Mar, 109:547–555
Nakagawa, Clinical Drug Investigation. 2006, 26(5):235–246
Kapp et al., Journal of Dermatological Treatment. 2003, 14(Suppl. 1):5-16