1. Global Overview of the Microbiome: Beyond HIV
Alan Landay, PhD
Professor and Chairman
Department of Immunology/Microbiology
Rush University Medical Center
Chicago, Illinois

2. ll 1
Lita Proctor
HMP

3. Conflict of Interest
None

5. Meta-
bolomics

6. Human Microbiome Project

7. Particular Interest in the Virome

8. The Human Mycobiome

9. What do we know about the gut microbiome in health?

10. Intestinal microbiota
>1014 microorganisms in GIT making us 90% bugs and 10% “us”!
Microbiota=the collective microorganisms
Microbiome=the collective gene content of those microorganisms
“Dysbiosis”= dysregulated (abnormal) microbiota. Common to many diseases including diabetes, colon cancer, and IBD
Site specific microbiota in GIT

11. Composition and luminal concentrations of dominant microbial species in various regions of the gastrointestinal tract.
Gastroenterology (2)

12. The gut microbiota during the human lifespan

13. The Western Microbiota Diverges from That of Non-Western Populations

14. What is happening in the gut in HIV ?

17. Therapeutic role of the Microbiome in HIV

18. Dillon AIDS 2016

19. Future Directions
Studies on Metagenomics, Metatranscriptomics, Metabolomics
Extend work to Virome and Mycobiome
Define Interactions of Gut Microbiome with Mucosal Immune System and Epithelial Cell Biology
Move beyond the Gut to Female Genital Tract, Lung, Oral, Skin, Breast Milk Microbiome

20. Acknowledgements University of Colorado University of Alcala
Stephanie Dillon Sergio Serrano-Villar
Cara Wilson