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Nanomedicine: Nanotechnology, Biology and Medicine

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1 Nanomedicine: Nanotechnology, Biology and Medicine
Self-powered therapeutic release from conducting polymer/graphene oxide films on magnesium  Kasey Catt, PhD, Huaxiu Li, BS, Victor Hoang, BS, Roland Beard, BS, X. Tracy Cui, BS  Nanomedicine: Nanotechnology, Biology and Medicine  DOI: /j.nano Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 PEDOT/GO/Dex Mg morphology.
(A) 20× image of PEDOT/GO/Dex coated Mg showing the uniform coating. (B) 100× image of PEDOT/GO/Dex coated Mg. (C) 500× image of PEDOT/GO/Dex coated Mg where the morphology provided by the GO sheets can be seen. Nanomedicine: Nanotechnology, Biology and Medicine DOI: ( /j.nano ) Copyright © 2017 Elsevier Inc. Terms and Conditions

3 Figure 2 Electrochemical impedance spectroscopy (EIS).
(A) Nyquist plots from PEDOT/GO coatings on Mg. (B) Nyquist plots from PEDOT/GO/Dex coated Mg and Uncoated Mg. Nanomedicine: Nanotechnology, Biology and Medicine DOI: ( /j.nano ) Copyright © 2017 Elsevier Inc. Terms and Conditions

4 Figure 3 Tafel scan. Current output from voltages applied during Tafel scan for PEDOT/GO on Mg, PEDOT/GO/Dex on Mg, and uncoated Mg. Nanomedicine: Nanotechnology, Biology and Medicine DOI: ( /j.nano ) Copyright © 2017 Elsevier Inc. Terms and Conditions

5 Figure 4 Hydrogen evolution.
Evolved hydrogen from PEDOT/GO/Dex coated Mg and uncoated Mg. (* p>0.05, all other p<0.05). Nanomedicine: Nanotechnology, Biology and Medicine DOI: ( /j.nano ) Copyright © 2017 Elsevier Inc. Terms and Conditions

6 Figure 5 Powered drug release.
Dex release resulting from applied reducing potential on PEDOT/GO/Dex Mg and drug release from PEDOT/GO/Dex Mg without stimulation. (* P>0.05, all other data points P<0.05). Nanomedicine: Nanotechnology, Biology and Medicine DOI: ( /j.nano ) Copyright © 2017 Elsevier Inc. Terms and Conditions

7 Figure 6 Corrosion driven drug release.
Dex release from PEDOT/GO/Dex films on Mg where drug release is powered by Mg corrosion. Mg samples had either long or short exposed area but the same amount of coverage by the PEDOT/GO/Dex coating (see schematic). (* P<0.05). Nanomedicine: Nanotechnology, Biology and Medicine DOI: ( /j.nano ) Copyright © 2017 Elsevier Inc. Terms and Conditions

8 Figure 7 Dex bioactivity.
Assessment of Dex bioactivity through quantification of NO generated by HAPI cells due to LPS+IFNɤ stimulation using Griess Assay. n=4 for each group (* P<0.05). Nanomedicine: Nanotechnology, Biology and Medicine DOI: ( /j.nano ) Copyright © 2017 Elsevier Inc. Terms and Conditions

9 Nanomedicine: Nanotechnology, Biology and Medicine DOI: (10. 1016/j
Nanomedicine: Nanotechnology, Biology and Medicine DOI: ( /j.nano ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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