1. Stem Cells and Osteoporosis
5/15/2018 9:31 PM
Stem Cells and Osteoporosis
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2. Stem Cells and Osteoporosis
1.5 Million Osteoporosis related fractures per year
Current Osteoporosis Treatments
Bisphosphonates are the most common medications prescribed for osteoporosis treatment. These include:
Alendronate (Fosamax)
Risedronate (Actonel)
Ibandronate (Boniva)
Zoledronic acid (Reclast)
Hormones
Estrogen
Hormone-like Medications
Raloxifene (Evista)
None of the above medications have ever been shown to form new bone, or increase bone density, but rather possible slowing down bone loss only.

3. Stem Cells and Osteoporosis
Teriparatide (Forteo)
Only osteoporosis drug which has ever been shown to have the potential to rebuild bone.
Made by bacteria (E. Coli)
Typically used in those who have already had a fracture related to Osteoporosis.
Recombinant human parathyroid hormone, used by injection
May increase risk of bone cancer (osteosarcoma)
May cause loss of normal bone marrow
Bodenner D, Redman C, Riggs A. Teriparatide in the management of osteoporosis. Clin Interv Aging Dec; 2(4): 499–507.

4. Stem Cells and Osteoporosis
How can Stem Cells help Osteoporosis?
Stem Cells can form “Osteocytes”, which are bone cells
Stem Cells which are capable of forming Osteocytes can be isolated from blood; they are called or “Small Embryonic-Like Stem Cells” “VSELs”
VSELs are formed by the Bone Marrow and then released into the blood stream; they are inactive in blood, waiting for a process to activate them Osteocytes
VSELs can be activated by cold temperature
Once active, VSELs will go to work seeking out areas of inflammation and disease

5. Stem Cells and Osteoporosis
Patient Case Study:
65 year old female
Known severe Osteoporosis of the lumbar spine and femur
Not responding to conservative treatment
Rapid decline in bone density with high fracture risk
Treatment: VSEL Stem Cells by IV infusion August 2015, September 2016

6. Stem Cells and Osteoporosis
Bone Density test results Left Hip:
VSEL VSEL

7. Stem Cells and Osteoporosis
Bone Density rest results Lumbar Spine (low back):
VSEL VSEL

8. Stem Cells and Osteoporosis
Case Study Results:
16% improvement in lumbar spine bone density
Patient bone density changed from “severe” to “mild” osteoporosis
after only 2 treatments (1 yearly)
5% improvement in left hip bone density
Significant reduction in fracture risk
Stem cells taken from patient’s own blood
No complications or side effects