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Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—A double-blinded, placebo-controlled randomized.

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Presentation on theme: "Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—A double-blinded, placebo-controlled randomized."— Presentation transcript:

1 Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—A double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive  Malin Gingnell, Jonas Engman, Andreas Frick, Lena Moby, Johan Wikström, Mats Fredrikson, Inger Sundström-Poromaa  Psychoneuroendocrinology  Volume 38, Issue 7, Pages (July 2013) DOI: /j.psyneuen Copyright © 2012 Elsevier Ltd Terms and Conditions

2 Figure 1 The emotion task (A) and the sensory-motor control task (B). Participants were requested to compare the top target slide with the two lower images and indicate which one expressed the same emotion or had the same form as the target. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2012 Elsevier Ltd Terms and Conditions

3 Figure 2 Subject flow and allocation to the intervention and control conditions. Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2012 Elsevier Ltd Terms and Conditions

4 Figure 3 During the last week of the treatment cycle COC users had lower reactivity in the left insula than placebo users (Tailarach coordinates: −33, 22, −17, cluster size: 21voxels). Brighter colors indicate higher T-scores. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.) Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2012 Elsevier Ltd Terms and Conditions

5 Figure 4 Compared to the pretreatment cycle, women randomized to placebo had lower right amygdala reactivity during last week of treatment (Tailarach coordinates: 27, 1, −17, cluster size: 4voxels). Brighter colors indicate higher T-scores. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.) Psychoneuroendocrinology  , DOI: ( /j.psyneuen ) Copyright © 2012 Elsevier Ltd Terms and Conditions


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