1. Intelligent predictive artificial pancreas by biomimicry of the native beta cells – concept, prototype and the future
Nils Kristian Skjærvold1,2,3, Anders Fougner1,4, and Nicolas-Andreas Elvemo5
1Artificial Pancreas Trondheim – the APT research group ( Norwegian University of Science and Technology, Trondheim, Norway; 2St Olavs University Hospital, Trondheim, Norway; 3Dept. of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 4Dept. of Engineering Cybernetics, Norwegian University of Science and Technology, Trondheim, Norway; 5GlucoSet AS, Trondheim, Norway
Artificial pancreas
The Algorithm
Glucoset sensor
References
Subject
Control algorithm
Glucose sensing
Insulin
infusion
Skjaervold NK, Solligard E, Hjelme DR, Aadahl P. Continuous measurement of blood glucose: validation of a new intravascular sensor. Anesthesiology 2011; 114(1): 120-5
Skjaervold NK, Lyng O, Spigset O, Aadahal P. Pharmacology of intravenous insulin administration: implication for future closed loop glycemic control by the intravenous/intravenous route. Diabetes technology and therapeutics 2012; 14(1): 23-9
Skjaervold NK, Ostling D, Hjelme DR, Spigset O, Lyng O, Aadahl P. Blood glucose control using a novel continuous blood glucose monitor and repetitive intravenous insulin boluses: exploiting natural insulin pulsatility as a principle for a future artificial pancreas. International journal of endocrinology 2013; 2013:
Insulin Pharmacology
Regulatory Idea
Preliminary results 3 4 5 6 7 20 40 60
Bloodglucose (mmol/l)
Time (min)
Time
Blood glucose
Optimal curve
High dose infusion stopped
= bolus infusion
Low dose infusion
High dose infusion
Biomimicry of the native beta cells
The Future
Intraperitoneal aproach?
Wearable system
Implantable system (inclusive insulin reservoir)?
Minimizing the delays
Pulsing the insulin administration
Liver/peripheral tissue insulin ratio