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Gul Daglar, M. D. , Turgut Karaca, M. D. , Yunus Nadi Yuksek, M. D

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Presentation on theme: "Gul Daglar, M. D. , Turgut Karaca, M. D. , Yunus Nadi Yuksek, M. D"— Presentation transcript:

1 Effect of Montelukast and MK-886 on Hepatic Ischemia-Reperfusion Injury in Rats 
Gul Daglar, M.D., Turgut Karaca, M.D., Yunus Nadi Yuksek, M.D., Ugur Gozalan, M.D., Filiz Akbiyik, M.D., Ph.D., Cenk Sokmensuer, M.D., Bora Gurel, M.D., Nuri Aydin Kama, M.D.  Journal of Surgical Research  Volume 153, Issue 1, Pages (May 2009) DOI: /j.jss Copyright © 2009 Elsevier Inc. Terms and Conditions

2 FIG. 1 Histology of the liver in the control and treatment groups. (A) The I/R group showed extensive panacinar congestion. (B) In control+LT inhibition groups, minimal damage mostly in zone 3 and megamitochondri were seen. (C) In I/R+LT inhibition groups, only zone 2 and/or 3 involvement with megamitochondri and microvesicular fatty change were observed (A, HE staining; original magnification, 100×; B and C, HE staining; original magnification, 200×). (Color version of figure is available online.) Journal of Surgical Research  , 31-38DOI: ( /j.jss ) Copyright © 2009 Elsevier Inc. Terms and Conditions

3 FIG. 2 Histology of the small intestine in the control and treatment groups. (A) The I/R group showed 2/3 of villus loss, apoptotic fragmentation, congestion and lymphatic dilation, villi denudation. (B) In control+LT inhibition groups, limited lymphatic dilation and preservation of villi structures were seen. (C) In I/R+LT inhibition groups, 1/3 loss of villi and superficial epithelial sloughing were seen (HE staining; original magnification, 200×). (Color version of figure is available online.) Journal of Surgical Research  , 31-38DOI: ( /j.jss ) Copyright © 2009 Elsevier Inc. Terms and Conditions

4 FIG. 3 Hepatic and intestinal mean apoptotic cells in groups.
Journal of Surgical Research  , 31-38DOI: ( /j.jss ) Copyright © 2009 Elsevier Inc. Terms and Conditions

5 FIG. 4 Hepatic and intestinal MDA levels in groups.
Journal of Surgical Research  , 31-38DOI: ( /j.jss ) Copyright © 2009 Elsevier Inc. Terms and Conditions

6 FIG. 5 Hepatic and intestinal GSH levels in groups.
Journal of Surgical Research  , 31-38DOI: ( /j.jss ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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