1. Switch to RAL-containing regimen
ARV-trial.com
Switch to RAL-containing regimen
Canadian Study
CHEER
Montreal Study
EASIER
SWITCHMRK
SPIRAL
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2. Canadian Study: Switch ENF to RAL
Pilot, open-label study
35 adults on salvage therapy with enfuvirtide-based regimen and HIV-1 RNA < 50 c/mL
Switch of enfuvirtide to RAL 400 mg bid, the remainder of the salvage regimen being unchanged. At the time of the switch:
ENF had been administered for a median of 25 months
HIV-1 RNA was < 50 c/mL for a median of 24 months
Salvage regimen: 1 to 4 NRTIs, 1 NNRTI in 6 patients, 1 to 2 PIs
Median follow-up of 7 months (range 1-13 months)
34/35 patients maintained HIV-1 RNA < 50 c/mL
1 single blip at 60 c/mL
ENF-related injection site reactions resolved in all patients
RAL was well tolerated
Canadian
Harris M, AIDS 2008;22:1224-6