1. Metabolic Networks OF Fruit-fly
Shiguo deng,huijie yang
Oct.17th .2010

2. Outline
Problems
Measures
Results

3. 1. Fruit-fly

6. There are significant differences between the genes

7. From the viewpoint of sequence alignments
SIGNIFICANT DIFFERENCES Between the 12 fruit-fly.
Problems:
The differences between the metabolic networks;
The relationship between the metabolic networks
with environmental effects (temperature, habitats,
Oxygen, and so on)

8. 1) Reconstruction of the metabolic networks
2. Methods
1) Reconstruction of the metabolic networks
KEGG database
### Arthropods
#### Insects
T00030(2000) dme D.melanogaster Drosophila melanogaster (fruit fly)
T01032(2007) dpo D.pseudoobscura Drosophila pseudoobscura pseudoobscura
T01059(2008) dan D.ananassae Drosophila ananassae
T01060(2008) der D.erecta Drosophila erecta
T01063(2008) dpe D.persimilis Drosophila persimilis
T01064(2008) dse D.sechellia Drosophila sechellia
T01065(2008) dsi D.simulans Drosophila simulans
T01067(2008) dwi D.willistoni Drosophila willistoni
T01068(2008) dya D.yakuba Drosophila yakuba
T01061(2008) dgr D.grimshawi Drosophila grimshawi
T01062(2008) dmo D.mojavensis Drosophila mojavensis
T01066(2008) dvi D.virilis Drosophila virilis
It is Very recently (2008) that the enzymes occur in each fruit-fly are available

9. 2) Overlapping of the metabolic networks
similarity
Distributions on networks
C(overlapping): the shortest paths
Between the overlapping nodes
C(total): the shortest paths between
All the nodes

10. 3) Comparatively Special Parts
Distributions of the special parts in PATHWAYS
The occurring number in Pathway#A
of the special metabolites in fruit-fly#i

11. 4) Seed sets of metabolites
The metabolites that must be provided by environments
Phyletic pattern
The coherent patterns
The patterns for the seed
metabolites correspond to
ENVIROMNETAL CAHNGES

12. 3. Some results TOTALLY data for 10 fruit-flies are available
Species j
Species i
Pair # of
i and j

13. similarities

15. Distributions of overl/non-overlapping parts

17. Seed sets: Distribution in pathways

18. Seed sets: Distribution in pathways

19. Tree of life: reconstruct from DNA alignment

20. Tree of life: reconstruct from Phyletic Patterns of Metabolite

21. Tree of life: reconstruct from Phyletic Patterns of Metabolite SEEDS

22. The End 3Q