1. cell cycle
김다은
성균관대학교 / 약학과

2. Contents Cell Cycle Introduction Interphase M Phase
Cell Cycle check-point
Cell Cycle regulator

3. Cell cycle Cell division / DNA duplication <Mother cell>
<Daughter cells>

4. Interphase : Preparation
Cell cycle
Interphase : Preparation
Cell cycle
Interphase는 전체 세포주기의 90%이상을 차지
Mitotic phase
(M-Phase)
: Division

5. Cell cycle_InterphaseG1
M - S
Cell growth
Cell growth checkpoint S
G1 – G2
DNA replication
DNA synthesis checkpoint G2
S -
Cell grow more
G1: M기 종료~DNA synthesis 시작 까지를 가리킴

6. Cell cycle_M Phase Prophase Metaphase Anaphase Prometaphase Telophase
&Cytokinesis
Prometaphase

7. Cell cycle checkpoint G1 checkpoint G2 Checks for spindle M
Cell division or not
Checks for Cell size, nutrients, DNA damage G1
checkpoint
Checks for DNA damage, DNA replication completeness
DNA repair or apoptosis G2
Checks for spindle M

8. Cell cycle regulator Prometaphase G1 – Rb protein phospholylation
G1 / S – induce of initiation of DNA replication
S – DNA replication
M – Spindle formation
Prometaphase

9. Tumor suppressor DNA damage DNA repair p53 Prometaphase apoptosis
Cyclin D
/ Cdk4&6
E2F + Rb
E2F
Cyclin E
(S phase) Rb p
p21