1. Risk of gastrointestinal bleeding with direct oral anticoagulants: a systematic review and network meta-analysis 
Nick Burr, MBBS, Katie Lummis, MBChB, Ruchit Sood, MBChB, John Samuel Kane, MBChB, Aaron Corp, MBChB, Dr Venkataraman Subramanian, MD 
The Lancet Gastroenterology & Hepatology 
Volume 2, Issue 2, Pages (February 2017)
DOI: /S (16)
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2. Figure 1 Study selection
ISTH=International Society on Thrombosis and Haemostasis. ICD-9=International Classification of Diseases, 9th revision.
The Lancet Gastroenterology & Hepatology 2017 2, 85-93DOI: ( /S (16) )
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3. Figure 2
Network plot
Each treatment is represented by a circle. The size of the circle is proportional to the number of patients on this drug. The thickness of the connecting line represents the number of studies comparing the two drugs.
The Lancet Gastroenterology & Hepatology 2017 2, 85-93DOI: ( /S (16) )
Copyright © 2017 Elsevier Ltd Terms and Conditions

4. Figure 3
Forest plot of the risk of (A) major gastrointestinal bleeding and (B) all gastrointestinal bleeding with different anticoagulants
Bayesian network meta-analysis. Vague and informative prior results are shown. IRR=incidence rate ratio. CrI=credible interval.
The Lancet Gastroenterology & Hepatology 2017 2, 85-93DOI: ( /S (16) )
Copyright © 2017 Elsevier Ltd Terms and Conditions

5. Figure 4
League table ranking anticoagulants in the order of risk of (A) major gastrointestinal bleeding and (B) all gastrointestinal bleeding
Results shown as incidence rate ratios (IRRs) with 95% credible intervals. (A) Major gastrointestinal bleeding as defined by International Society on Thrombosis and Haemostasis or International Classification of Diseases, 9th revision, criteria. Results do not reach statistical significance. (B) All gastrointestinal bleeding is defined as the total number of bleeding events for which severity was not defined in the study.
The Lancet Gastroenterology & Hepatology 2017 2, 85-93DOI: ( /S (16) )
Copyright © 2017 Elsevier Ltd Terms and Conditions