1. Plant stanol esters in low-fat yogurt reduces total and low-density lipoprotein cholesterol and low-density lipoprotein oxidation in normocholesterolemic and mildly hypercholesterolemic subjects
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2. Rationale
9.8% of Koreans aged 30 years and older have high cholesterol levels and 27.6% have moderately high cholesterol levels, which is an important risk factor for the development of cardiovascular disease
The aim of the study was to determine the effects of a low-fat yogurt containing plant stanol esters on serum lipids and LDL oxidation in Korean adults with normocholesterolaemia and mild hypercholesterolaemia
*DALY; disability-adjusted life years
Hyun YJ et al. Nutrition Research. 2005;25:

3. Design Randomised, double-blind, placebo-controlled study
Subjects received yogurt containing either plant stanol 2 g/d (plant stanol esters 3.3 g/d) or placebo
Hyun YJ et al. Nutrition Research. 2005;25:

4. Patient population Inclusion criteria: Age 20-39 years
Fasting serum cholesterol mg/dl
Fasting serum triacylglycerols <266 mg/dl
No lipid-lowering medication
Normal function of liver, kidney, and thyroid
No history of unstable coronary artery disease within the previous 6 months
No diabetes
No temporary ischaemic attack
No malignant disease
No alcohol abuse
No pregnancy
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5. Protocol
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6. Results I
Plant stanol lowered significantly total cholesterol level by 5.8% (p=0.001), LDL-cholesterol level by 9.8% (p <0.001), and plasma oxidised LDL by 5.4% (p <0.05) without affecting HDL- cholesterol and triacylglycerol concentrations. The placebo group showed no significant changes.
*DALY; disability-adjusted life years
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7. Results II Plant stanol 2 g/d Placebo
Figure 1. Plant stanol showed a significant lowering effect for total cholesterol and LDL- cholesterol vs. placebo after 4 weeks.
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8. Conclusion
Plant stanol esters contained in low-fat yogurt are effective in reducing total and LDL-cholesterol and oxidised LDL levels in a usual diet
*DALY; disability-adjusted life years
Hyun YJ et al. Nutrition Research. 2005;25:

9. Editor’s note
“Foods containing plant stanols might be a useful tool for normocholesterolaemic and mildly hypercholesterolaemic individuals to prevent severe hypercholesterolaemia and cardiovascular disease.”
*DALY; disability-adjusted life years
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