1. History of Neurology Charcot et Lés Peeps
Richard J. Barohn, MD
February 3, 2017

2. Jean Martin Charcot (1825-1893)
“The Founder of Modern Neurology”
Established clinical neurology as a discipline 1882 – 1st chair of disease of nervous system
Son of a cabinet maker
Difficulty passing oral exams
Superintendent of Salpêtrière, Paris, France at age 37 (housed 5-10k “welfare” medical inmates)
ALS, MS, myopathy & neuropathy cases, tabes dorsalis & Charcot Joints
Clinical pathologic correlations
Classroom demonstrations – Leçons (Tue & Fri)
Hysteria/Hypnosis later in career
Anti-animal research

9. Descendants of Charcot
Marie
Babinski
Dejerine
Roussy
De la Tourette
Piranaud
Freud
Janet
Brissaud
Marinesco
Bourneville
Bekhterev

10. History of Neurology France Late 1800’s - Salpêtrière
Pierre Marie ( )
Paris, France
Cerebellar ataxia/spinal AVM
Charcot-Marie-Tooth
Revue médicale (1886)
Lectures on the Diseases of the Spinal Cord (1895)
Joseph François Félix Babinski ( )
Extensor sign
Joseph Jules Dejerine ( )
Paris, France (B: Geneva, Switzerland)
FSH MD
Pain Syndrome
Gustave Roussy ( )
Paris, France (B: Vevey, Switzerland)
Pain syndrome
Neuropathy
Marie
Babinski
Dejerine
Roussy

11. History of Neurology France Late 1800’s - Salpêtrière
Georges Gilles de la Tourette ( ) Paris, France
Tourette's Syndrome – TICS
Henri Parinaud ( ) Paris, France
Dorsal Midbrain Syndrome
Vertical Gaze Palsy
Pineal Tumor
Édouard Brissaud ( ) Paris, France
Locus niger lesion site in PD
Double innervation of Face
Chair at Salpêtrière after F. Raymond who succeeded Charcot
Pierre Janet ( ) Paris, France
One of Founding Fathers of Psychology
Developmental hierarchy
Desire Magloire Bourneville ( ) Paris, France
Tuberous Sclerosis
Edited Leçons
Gille de la Tourette
Parinaud
Brissaud
Janet
Bourneville

12. Pierre Marie Chef de laboratoire under Charcot
At age 60, he succeeded Dejerine in Charcot’s chair

13. Dejerine Eponyms Dejerine's "onion-peel sensory loss"
Dejerine's cortical sensory syndrome
Dejerine-Mouzon syndrome
Dejerine syndrome: medial medullary syndrome
Dejerine-Klumpke paralysis (Augusta Marie Klumpke was his American wife)
Dejerine-Roussy syndrome
Dejerine-Sottas disease
Dejerine-Thomas olivopontocerebellar atrophy
Landouzy-Dejerine syndrome

14. History of Neurology France Late 1800’s – Salpêtrière Visiting Scholars
Sigmund Freud ( )
Vienna, Austria
Briefly Charcot’s visiting “Fellow”
Georges Marinesco ( )
Bucharest, Romania
1897 Chair, Neurology at U. of Bucharest
250 papers
Inclusions in substantia nigra
Familial amaurotic idiocy
Vladimir Bekhterev ( )
Moscow, Russian
Scholarship abroad with Charcot, Meynert, Westphal, Flechig
Clinical neurology & experimental psychology in St. Petersburg & Leningrad
Freud
Marinesco
Bekhterev

15. Then… Salpêtriére WAYS PHYSICIANS DISCUSS NEUROLOGY
A Clinical Lesson at the Salpetriere, Andre Brouillet (1887); hangs in corridor of the Descartes University in Paris

16. Now…
Richard Barohn, Mazen Dimachkie, Mamatha Pasnoor, Jeffrey Statland, Jon Katz, Todd Levine, David Saperstein, Katalin Scherer, Aziz Shaibani, Mike Pulley, Tony Amato, Carlayne Jackson, Osvaldo Nascimento, John Kissel, Sara Austin, Tahseen Mozaffar, Anthony Amato, Gil Wolfe, Matt Wicklund, Jaya Trivedi, Omar Jawdat, Laura Herbelin