1. 100
200
300
400
500
600
700
No muscle wasting
Muscle wasting
6-minute walk (m)
P=0.003
Figure 1a
500
750
1000
1250
1500
1750
2000
2250
2500
2750
3000
No muscle wasting
Muscle wasting
Absolute peak VO2 (ml/min)
P < 0.05
Figure 1b

2. 15 20 25 30 35 40 45 50 55 60 C
E/e'≥15 B
E/e' 9-14 A
E/e'≤8
PANOVA=0.0003
Right handgrip strength (kg)
Figure 2a 20 30 40 50 60 70 80
Right quadriceps strength (kg) C
E/e'≥15 B
E/e' 9-14 A
E/e'≤8
PANOVA=0.002
Figure 2b

3. 5 10 15 20 25 30 35 40
Appendicular lean mass (kg)/BMI
E/e'
P=0.02
R=-2.2
Figure 3

4. Absolute peak VO2 (ml/min)
500
750
1000
1250
1500
1750
2000
2250
2500
2750
3000 15 20 25 30 35 40
Appendicular lean mass (kg)
P <
R=0.67
Figure 4

5. 20 30 40 50 60 70 80 90
100 2 3 4 5 6 7
Vas-Score
P=0.0005
R=0.50
Figure 5a
Vas-Score 20 30 40 50 60 70 80 90
100 2 3 4 5 6 7
P= 0.01
R=0.38
Figure 5b
Muscle strength/muscle mass in the left leg (both in kg)
Muscle strength/muscle mass in the right (both in kg)