1. Coronary Heart Disease, Diabetes, and Sexuality in Men
Geoff Hackett, MD, FRCPI, MRCGP, Michael Krychman, MD, David Baldwin, MBBS, DM, FRCPsych, Nelson Bennett, MD, FACS, Ahmed El-Zawahry, MD, Alessandra Graziottin, MD, Monika Lukasiewicz, MD, Kevin McVary, MD, Yoshikazu Sato, MD, PhD, Luca Incrocci, MD, PhD 
The Journal of Sexual Medicine 
Volume 13, Issue 6, Pages (June 2016)
DOI: /j.jsxm
Copyright © 2016 International Society for Sexual Medicine Terms and Conditions

2. Figure 1
The progressive development of ED in association with comorbidities. At the early stage of endothelial dysfunction, changes could be reversible, but less so at the later stage of fixed atherosclerosis. Adapted from Saenz de Tejada et al.106 CV = cardiovascular; ED = erectile dysfunction.
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3. Figure 2
Endothelial dysfunction and comorbidities in erectile dysfunction and the central role of testosterone and angiotensin II on PDE5 expression (source author). NO = nitric oxide; PDE5 = phosphodiesterase type 5.
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4. Figure 3
Hazard ratio for CHD events stratified by erectile dysfunction in 2,306 men with type 2 diabetes mellitus and no CHD at baseline. Adapted from Ma et al.21 CHD = coronary heart disease.
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5. Figure 4
Association of depression and diabetes complications: strong links with sexual dysfunction in men and women—a meta-analysis. From de Groot et al.28 DM = diabetes mellitus.
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6. Figure 5
Suggested management algorithm to detect coronary artery disease in younger men presenting with ED. Adapted from Jackson.69 CCTA = coronary computed tomographic angiography; CVD = cardiovascular disease; ED = erectile dysfunction.
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7. Figure 6
Forest plots of risk factors for all-cause mortality in 7,860 men with type 2 diabetes mellitus followed up for 6.4 years. Anderson et al.61 AMI = acute myocardial infarction; BP = blood pressure; eGFR = estimated glomerular filtration rate; HbA1c = glycosylated hemoglobin; PDE5i = phosphodiesterase type 5 inhibitor.
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8. Figure 7
Testosterone replacement therapy and phosphodiesterase type 5 inhibitor use independently predicted all-cause mortality in 857 men with type 2 diabetes mellitus followed for 4 years.
From Hackett et al.62
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9. Figure 8
Kaplan-Meier survival curves show that low testosterone predicted mortality and testosterone therapy improved survival in 567 men with type 2 diabetes mellitus followed for 5.8 years.
Adapted from Muraleedaran et al.77
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10. Figure 9
Cardiovascular impact of testosterone therapy in 5,695 men with low testosterone levels—event rates (percentages) of MACEs at 1 and 3 years. Anderson et al.78 MACE = major adverse cardiovascular event.
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11. Figure 10
Normalization of testosterone was associated with decreased myocardial infarction and mortality in 83,010 men with a mean follow-up of 4.6 years. Therapy not resulting in normalization of levels did not decrease infarction rates or mortality.
From Sharma et al.79
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12. Figure 11
Forest plot shows the standardized difference in means of IIEF-5 score after lifestyle intervention only and pharmacotherapy for CV risk factors. From Ma et al.21 CV = cardiovascular; IIEF-5 = International Index of Erectile Dysfunction.
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13. Figure 12
Association of risk factors with acute myocardial infarction in men and women after adjustment for age, sex, and geographic region. Adapted from Yusuf36 ApoA1 = apolipoprotein A1; ApoB = apolipoprotein B.
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