1. Section 3: Cellular Respiration
Preview
Bellringer
Key Ideas
Glycolysis
Aerobic Respiration
Fermentation
Summary

2. Bellringer
Answer the following questions: How are the products of photosynthesis and respiration related? What kinds of organisms undergo cellular respiration?

3. Key Ideas How does glycolysis produce ATP?
How is ATP produced in aerobic respiration?
Why is fermentation important?

4. Glycolysis
The cells of most organisms transfer energy found in organic compounds, such as those in foods, to ATP.
The primary fuel for cellular respiration is glucose. Fats can be broken down to make ATP.
Proteins and nucleic acids can also be used to make ATP, but they are usually used for building important cell parts.

5. Glycolysis, continued
In glycolysis, enzymes break down one six-carbon molecule of glucose into two three-carbon pyruvate molecules.
The breaking of a sugar molecule by glycolysis results in a net gain of two ATP molecules.
This process of glycolysis is anaerobic, or takes place without oxygen.

6. Visual Concept: Glycolysis
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7. Glycolysis, continued
Glycolysis is the only source of energy for some prokaryotes.
Other organisms use oxygen to release even more energy from a glucose molecule. Metabolic processes that require oxygen are aerobic.
In aerobic respiration, the pyruvate product of glycolysis undergoes another series of reactions to produce more ATP molecules.

8. Glycolysis

9. Aerobic Respiration
Organisms such as humans can use oxygen to produce ATP efficiently through aerobic respiration.
The first stage of aerobic respiration is the Krebs cycle, a series of reactions that produce electron carriers.
The electron carriers enter an electron transport chain, which powers ATP synthase.
Up to 34 ATP molecules can be produced from one glucose molecule in aerobic respiration.

10. Aerobic Respiration, continued
Krebs Cycle
Pyruvate (from glycolysis) is broken down and combined with other carbon compounds.
Each time the carbon-carbon bonds are rearranged during the Krebs cycle, energy is released.
The total yield of energy-storing products from one time through the Krebs cycle is one ATP, three NADH, and one FADH2.

11. Visual Concept: Krebs Cycle
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12. Aerobic Respiration, continued
Electron Transport Chain
The second stage of aerobic respiration takes place in the inner membranes of mitochondria, where ATP synthase enzymes are located.
Electron carriers, produced during the Krebs cycle, transfer energy through the electron transport chain.
Energy from the electrons is used to actively transport hydrogen ions out of the inner mitochondrial compartment.

13. Visual Concept: Electron Transport Chain
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14. Aerobic Respiration, continued
Electron Transport Chain
Hydrogen ions diffuse through ATP synthase, providing energy to produce several ATP molecules from ADP.
At the end of the electron transport chain, the electrons combine with an oxygen atom and two hydrogen ions to form two water molecules.
If oxygen is not present, the electron transport chain stops. The electron carriers are not recycled, so the Krebs cycle also stops.

15. Fermentation
To make ATP during glycolysis, NAD+ is converted to NADH. Organisms must recycle NAD+ to continue making ATP through glycolysis.
The process in which carbohydrates are broken down in the absence of oxygen is called fermentation.
Fermentation enables glycolysis to continue supplying a cell with ATP in anaerobic conditions.

16. Fermentation, continued
In lactic acid fermentation, pyruvate is converted to lactic acid.
During vigorous exercise, lactic acid fermentation also occurs in the muscles of animals, including humans.
During alcoholic fermentation, one enzyme removes carbon dioxide from pyruvate. A second enzyme converts the remaining compound to ethanol, recycling NAD+ in the process.

17. Two Types of Fermentation

18. Fermentation, continued
Efficiency of Cellular Respiration
In the first stage of cellular respiration, glucose is broken down to pyruvate during glycolysis, an anaerobic process.
Glycolysis results in a net gain of two ATP molecules for each glucose molecule that is broken down.
In the second stage, pyruvate either passes through the Krebs cycle or undergoes fermentation. Fermentation recycles NAD+ but does not produce ATP.

19. Fermentation, continued
Efficiency of Cellular Respiration
Cells release energy most efficiently when oxygen is present because they make most of their ATP during aerobic respiration.
For each glucose molecule that is broken down, as many as two ATP molecules are made during the Krebs cycle.
The Krebs cycle feeds NADH and FADH2 to the electron transport chain, which can produce up to 34 ATP molecules.

20. Visual Concept: Comparing Aerobic and Anaerobic Respiration

21. Summary
The breaking of a sugar molecule by glycolysis results in a net gain of two ATP molecules.
The total yield of energy-storing products from one time through the Krebs cycle is one ATP, three NADH, and one FADH2.

22. Summary, continued
Electron carriers transfer energy through the electron transport chain, which ultimately powers ATP synthase.
Fermentation enables glycolysis to continue supplying a cell with ATP in anaerobic conditions.