1. Tissue Repair Clot Clean up Scab Restored blood supply Granulation
Regeneration and fibrosis
Fibrous tissue matures
Figure 4.12a

2. Barrier penetration / Tissue Trauma
Causes inflammation, characterized by: Vasodilation
Dilation of blood vessels
Increase in vessel permeability
Redness, heat, swelling (edema), and pain

3. Tissue repair - The inflammatory response
Histamine is released from mast cells in the C.T. And causes vasodilation.
Location of mast cells

5. Chemokines cause leukocyte extravasation

6. Leukocyte jobs
1. Neutrophils - 2. Macrophages - 3. Dead cells and fluid leaked from the capillaries may accumulate as pus in the area before it is absorbed by the body

7. Tissue repair - Granulation
Fibroblasts
Capillaries
Collagen
Figure 4.12b

8. Tissue Repair-Regeneration
regenerated e.t. with underlying scar tissue
Figure 4.12c