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Intensive Therapy before or during the Conditioning Regimen of Allogeneic Marrow Transplantation in Adult Acute Lymphoblastic Leukemia Patients: We Must.

Published byAriane Petit Modified over 6 years ago

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Presentation on theme: "Intensive Therapy before or during the Conditioning Regimen of Allogeneic Marrow Transplantation in Adult Acute Lymphoblastic Leukemia Patients: We Must."— Presentation transcript:

1 Intensive Therapy before or during the Conditioning Regimen of Allogeneic Marrow Transplantation in Adult Acute Lymphoblastic Leukemia Patients: We Must Choose to Reduce Toxicity—A Groupe Ouest-Est d’Etude des Leucémies et Autres Maladies du Sang Study  Eric Deconinck, Mathilde Hunault, Noël Milpied, Marc Bernard, Marc Renaud, Bernard Desablens, Martine Delain, Francis Witz, Bruno Lioure, Bernard Pignon, Denis Guyotat, Christian Berthou, Jean-Pierre Jouet, Phillipe Casassus, Norbert Ifrah, Jean-Michel Boiron  Biology of Blood and Marrow Transplantation  Volume 11, Issue 6, Pages (June 2005) DOI: /j.bbmt Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Protocol design of the LALPOF and GOELAL1 trials. CI indicates continuous infusion; CR, complete remission; DNR, daunorubicin; VCR, vincristine; ADA, daunorubicin + cytarabine + asparaginase; MAPO, methotrexate + cytarabine + prednisone + vincristine; BEAC, BCNU (carmustine) + etoposide + cytarabine + cyclophosphamide; ZAM, idarubicin + cytarabine + methylprednisolone; AZA, cytarabine + idarubicin + asparaginase; PAME, prednisolone + cytarabine + mitoxantrone + etoposide. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Survival according to the protocol assignment. At 48 months (4 years): LALPOF, 71% ± 12% (continuous line); GOELAL, 36% ± 13% (dotted line) (P = .009). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Disease-free survival according to the protocol assignment. At 48 months (4 years): LALPOF, 75% ± 11% (continuous line); GOELAL, 69% ± 13% (dotted line) (P = .30). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Event-free survival according to the protocol assignment. At 48 months (4 years): LALPOF, 66% ± 11% (continuous line); GOELAL, 35% ± 11% (dotted line) (P = .02). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

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