1. Hearing Loss in Sjögren’s syndrome: A cohort matched prospective observational study
Usama Kamel
MD, FRCSEd(Otol.), PGCPCE, MBBCh
ENT Dept, Queen’s Medical Centre,
Nottingham University Hospitals
Nottingham
England, UK
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Sjögren’s syndrome
SS is a multisystem autoimmune disease characterised by chronic inflammation of the exocrine glands
♀ : ♂ : % – 2.1%
It is the second most common autoimmune rheumatic disease after RA (Thomas et al 1998)
American-European Consensus Sjögren’s Classification Criteria for SS has established a clearer diagnostic framework (Vitali et al 2002)
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Previous studies
Deafness: Yes: 16 – 46%
HFSNHL, Cochlear
No: Trott et al (n=14), no controls
Freeman et al (n=137) retrospective
Tumiati et al (46%) n=30 (unclear SS Dx criteria)
Ziavara et al (22.5%) n=40
Boki et al. 2001(16%) n=48
Hatzopoulos et al (36%) n=22, no controls
Doig et al (1:21SSp, 7:31SSs), no controls
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Methods
A cohort matched, prospective, cross sectional observational study.
Ethical approval was granted. Patient and control subjects gave informed consent.
28 SS patients (F=25:M=3), mean age 59 years old (range 36–83) according to the American European Criteria for SS diagnosis .
34 controls (F=32:M=2) with mean age 56 years old (range 35–78)
This study was part of a larger project
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Pure Tone Audiometry
PTA was 0.25, 0.5, 1, 2, 3,4, 6& 8 KHz.
hearing threshold means for both groups were calculated at the above frequencies.
SPSS statistical package was used to analyse data.
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Results
Hearing acuity is highly correlated with age (Pearson p<0.001 (L), p<0.001 (R).
L & R ear results are very highly correlated (Pearson p<0.001).
Statistically, there were no significant differences between cases and controls for hearing loss.
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Right ear
SS group
Control group
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Left ear
SS group
Control group
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Discussion
This controlled study is the third in literature about deafness in SS – Dx
Freeman et al (n=137) retrospective
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Strength of the study
ENT examination, other senses and QoL in SS were studied
N=28 SS and 34 controls
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Weakness of the study
More patients
More audio-vestibular assessment
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Conclusion
SS does not appear to be associated with SNHL.
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Acknowledgements
Co workers: Prof Peter Maddison, Consultant Rheumatologist
Rhiannon Whitaker, Statistician, Bangor
R & D dept for supporting this project
Audiology Dept, YG
Outpatient clinic staff nurses, YG
Declaration:
Grant of £4990 from North Wales Research & Development Department to conduct this study as part of a larger project
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Thank you
8 June 2015
3rd Congress of European Otolaryngology HNS, Prague