1. D D ? ? D D ? ?Check sequences TAIR? E. coli? ? ISS IDA, IMP, IGI, IC
no EXP?
IDA, IMP, IGI, IPI
IDA
IDA, IMP, IPI
Human: P check D
no EXP?
no EXP?
no EXP? ?
?Check sequences

2. Molecular Function Questions:
GO term Hs Mm Rn Gg Dr Dm Ce Dd At Sc Sp Ec
GO: DNA topoisomerase (ATP-hydrolyzing) activity
IDA
IDA, IGI
IDA, IGI, IMP
IDA?
GO: DNA-dependent ATPase activity
GO: ATP binding ? IC
GO: DNA binding ?
GO: chromatin binding ?
GO: protein homodimerization activity ?
IPI
IPI?
GO: protein heterodimerization activity ?
Questions:
1. Should " GO: DNA topoisomerase (ATP-hydrolyzing) activity
" be a child of "GO: DNA-dependent ATPase activity", or does that create a TPV since its parent is not an ATPase?
2. Should substrate binding be captured for all organisms?
3. Should homo/heterodimerization be captured for all organisms?

3. Rejected for propagation of annotations (Molecular Function)
GO:
protein kinase C binding
human
IPI
GO:
protein binding
mouse
GO:
protein C-terminus binding
GO:
drug binding
IDA
GO:
histone deacetylase binding
GO:
ubiquitin binding
IMP
GO:
sequence-specific DNA binding
rat
GO:
satellite DNA binding
fly
GO:
mRNA binding
GO:
rDNA binding
GO:
four-way junction DNA binding

4. Biological Process Questions:
GO term Hs Mm Rn Gg Dr Dm Ce Dd At Sc Sp Ec
GO: DNA topological change
IDA?
IDA
IDA, IGI, IMP
GO: chromosome segregation
IMP
IDA, IMP
GO: mitotic chromosome condensation
GO: chromosome condensation
GO: apoptotic chromosome condensation
GO: transcription of nuclear rRNA large RNA polymerase I transcript
IGI
GO: positive regulation of retroviral genome replication
GO: positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-dependent
Questions:
Annotate to " GO: DNA ligation " (Human, IDA)? See definition of 'DNA topoisomerase activity; includes ligation
Should "DNA ligation" even be a process? Isn't it a single step?

5. Rejected for propagation of annotations (Biological Process)
GO:
reproduction
Worm
IMP
GO:
regulation of mitotic recombination
GO:
resolution of meiotic joint molecules as recombinants
GO:
cytokinesis
GO:
cell division
GO:
embryonic development ending in birth or egg hatching
GO:
embryonic cleavage
Mouse
GO:
positive regulation of apoptosis
Human
IDA
GO:
DNA strand elongation during DNA replication
Yeast
GO:
establishment or maintenance of chromatin architecture
Pombe
IGI
GO:
chromatin assembly or disassembly
GO:
chromatin silencing
Fly
GO:
mRNA export from nucleus
GO:
response to DNA damage stimulus
GO:
mitotic spindle organization
GO:
meiotic recombination
GO:
chromatin remodeling at centromere

6. Cellular Component Questions:
GO term Hs Mm Rn Gg Dr Dm Ce Dd At Sc Sp Ec
GO: DNA topoisomerase complex (ATP-hydrolyzing)
IDA
IDA?
GO: nucleus
Questions:
Should the definition of " GO: DNA topoisomerase complex (ATP-hydrolyzing)" be fixed?
Should " GO: DNA topoisomerase complex (ATP-hydrolyzing)" be a child of chromosome or chromatin?

7. Rejected for propagation of annotations (Cellular Component)
GO:
soluble fraction
fly
IDA
GO:
insoluble fraction
GO:
membrane fraction
e. coli
GO:
mitochondrion
S. cerevisiae
GO:
cytoplasm
fly, e. coli
GO:
synaptonemal complex
GO:
nucleoplasm
human
GO:
nucleolus
mouse
GO:
centriole
GO:
chromatin accessibility complex
GO:
condensed chromosome
GO:
chromosome
human , fly