1. Biochemistry Free For All
Lipids & Membranes
Biochemistry Free For All

2. The effects in a mouse on the inability to make leptin (left)
compared to a normal mouse

3. Saturated - no double bonds
Fatty Acids
Saturated - no double bonds
Cis double bond
Unsaturated - at least
one double bond

4. Saturated Fatty Acids

5. Unsaturated Fatty Acids

6. Fatty Acids - Space Filling Models

7. Fatty Acid Numbering Δ and ω Systems

8. Fatty Acids
Glycerol Backbone
Ester Bonds
Fat or Oil Structure

9. Hormonally controlled
Triacylglycerol Lipase
Diacylglycerol
Signaling
Molecule
Triacylglycerol Lipase
Monoacylglycerol Lipase
Pancreatic
Lipase

10. (Phosphatidyl Compounds)
Non-Polar End 1 2
Attachment
point for
phosphatidyl
compounds 3
Polar End
Phosphatides
(Phosphatidyl Compounds)

11. Phosphate of Phosphatides
Molecules Attached to
Phosphate of Phosphatides

12. Phosphatidylcholine

13. Phosphatidylinositol-B
Phospholipase C Cuts C
Phosphatidylinositol-
4,5 Phosphate (PIP2) A B C
Cytoplasm
Membrane bound

14. inner mitochondrial membrane
Cardiolipin
Almost exclusive to
inner mitochondrial membrane
Phosphatide
Phosphatide
Glycerol

15. Cardiolipin plays a role in apoptosis - programmed cell death

16. Plasmalogens
ROS Protection
Heart
Brain
Myelin Sheath

17. Non-polar End
Polar
End
Sphingolipids

19. Non-polar Tails
Sphingomyelin
Polar End

22. Precursor of Prostanoids & Thromboxanes
Eicosanoids
Cyclization by
Cyclooxygenase
Arachidonic Acid
Precursor of Prostanoids & Thromboxanes

23. Prostaglandin F2α (PF2α)
Thromboxane A2
Blood Clotting
Prostaglandin H2 (PGH2)
Precursor of Others
Leukotriene A4
Blood Clotting
Prostaglandin F2α (PF2α)
Uterine Contractions

24. Tetrahydrocannabinol
Anandamide
(Endocannabinoid)
Tetrahydrocannabinol
(Phytocannabinoid)

25. General Steroid Structure
Cholesterol
Phytotosterol
General Steroid Structure

26. Aldosterone
(Mineralocorticoid)
Testosterone
(Androgen)
Progesterone
(Progestagen)
Cortisol
(Glucocorticoid)
Estradiol
(Estrogen)

27. Vitamin A Vitamin A All-trans Retinol All-trans Retinal Vitamin A
Involved in vision
Vitamin A
11-cis Retinal
β-carotene

28. Cholecalciferol
Vitamin D
Calcitriol
Active Vitamin D
α-Tocopherol
Vitamin E
Vitamin K

35. Lipid Movement Across Lipid Bilayer Lateral (within one bilayer)
Transverse (from one side to the other)

36. Lateral Movements
Lateral Movements

37. Transverse Movements
Transverse Movements

38. Cholesterol in the Lipid Bilayer

39. Cholesterol widens range but doesn’t change midpoint (Tm)

40. Longer/more saturated fatty acids increase Tm
Shorter /more unsaturated
fatty acids decrease Tm