1. Volume 100, Issue 2, Pages 226-237 (February 2006)
Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects 
Britt-Marie Larsson, Maria Kumlin, Britt-Marie Sundblad, Kjell Larsson, Sven-Erik Dahlén, Lena Palmberg 
Respiratory Medicine 
Volume 100, Issue 2, Pages (February 2006)
DOI: /j.rmed
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2. Figure 1
Study design. Twenty-three healthy subjects treated with zileuton (n=11) or placebo (n=12) for 5 days prior to exposure in a swine house. NAL=nasal lavage, NO=nitric oxide, PEF=peak expiratory flow.
Respiratory Medicine  , DOI: ( /j.rmed )
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3. Figure 2
Bronchial responsiveness to methacholine before and after exposure in a swine confinement house in 12 healthy subjects treated with placebo and 10 healthy subjects treated with zileuton. The exposure induced a decrease in PD20FEV1 in all subjects. Horizontal lines indicate median values. **P<0.01 for pre- and post-exposure comparisons. Data from one subject was excluded from the statistical analysis due to a technical error during the methacholine provocation test.
Respiratory Medicine  , DOI: ( /j.rmed )
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4. Figure 3
LTE4 (A) and 9, 11-PGF2 (B) and in urine samples collected from 11 subjects treated with zileuton and 12 subjects treated with corresponding placebo. Pre-exposure values are the mean value of two samples collected in the afternoon the day before exposure. Post-exposure values are the mean of two samples collected in the afternoon after the exposure. There was a significant difference between the groups regarding the change in concentration of 9, 11-PGF2 (P<0.05) but not for LTE4. Mean (95% confidence interval) and individual values. *, P<0.05; **, P<0.01 for pre- and post-exposure comparisons.
Respiratory Medicine  , DOI: ( /j.rmed )
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5. Figure 4
Total cell concentration (A), the concentration of IL-6 and IL-8 (B) and the concentration of LTB4 and LTEC4 (C), in NAL fluid before and after five days of medication and after exposure to swine dust. Open circles represent placebo (n=12) and filled circles represent zileuton (n=11) treatment. Significant increases were observed in total cell concentration and cytokine levels in both groups following exposure. LTB4 levels decreased after 5 days of zileuton treatment, and were not further influenced by the exposure. The placebo group demonstrated significantly elevated levels of LTB4 after exposure. Levels of LTE4 were not affected by drug pre-treatment or exposure. There were no significant differences between the groups except for LTB4 (P<0.05). Median and interquartile range are presented. *, P<0.05; **, P<0.01; ***, P<0.001 for pre- and post-exposure comparisons, # indicates significant differences between the groups.
Respiratory Medicine  , DOI: ( /j.rmed )
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6. Figure 5
Cellular reactions (A) and IL-6 (B) in peripheral blood before, and during medication and after exposure to swine house dust. Open circles represent placebo (n=12) and filled circles represent zileuton (n=11) treatment. The increase in concentration of neutrophils and monocytes differed significantly between the groups (P<0.05). IL-6 increased significantly more in the zileuton group than in the placebo group (P<0.001). Open circles represent placebo and filled zileuton. Median and interquartile range are presented. *, P<0.05; **, P<0.01; ***, P<0.001 for pre- and post-exposure comparisons, # indicates significant differences between the groups.
Respiratory Medicine  , DOI: ( /j.rmed )
Copyright © 2005 Elsevier Ltd Terms and Conditions