1. Estrogen & Estrogen Receptor

2. Target tissues of estrogen in females & males
“Good” estrogen actions
“Bad” estrogen actions
Maintain bone
Promoter proliferation of
Maintain sexual function
Cardiovascular protection
Mammary epithelium
Protect brain function
Endometrial epithelium

3. Estrogen receptor (ER) signaling pathways
NEJM 2006;354:270-82
Ovarian steroid hormone

4. Effects of ER on different cell types

5. Estrogen receptor and Breast cancer

6. Role of E2/ER in breast carcinogenesis
Initiators
Promoters
ER positive

7. Functional domains & expression of human ERs
Phosphorylation
Acetylation
cys447
Palmitoylation
Expression
breast, uterus,
and bone
ovary, prostate,
testis, lung,
thymus, spleen,
and brain

8. Regulation of ER activity by multiple coregulators

9. Chromatin modification in ER-mediated transcription

10. Transcriptional regulation modes of
nuclear receptors