1. Trends in Human Genetics and Molecular Biology
Koh Chong Lek
Head, Research Business Unit, HIR, UM

2. Interactive session on a number of topics – your participation
A fruitful session of benefits to you

3. Structure and function
Individual
Growth/Development
Systems
Differentiation
Organs
Tissues
Regulation
Cells
Structure and function

4. Basic + applied Evolution
Individual
Horizontal
Systems
Organs
Tissues
Environment
Cells
Interaction
Vertical
Phylogeny
Offspring
Basic + applied
Evolution

5. Possibilities Exciting time
Cutting edge, innovative technologies + Ideas
Possibilities

6. 1973: Molecular cloning Genetic engineering
1975: Sanger dideoxy chain termination and elongation method
1983: PCR, the polymerase chain reaction
2000: More creative at sequencing DNA at micro and nano levels Next-Generation Sequencing

7. Transcriptome, transcriptomics
Advances in molecular and biochemical techniques and bioinformatics: New “omes” and “omics” began to appear in the English language
Genome, genomics
Proteome, proteomics
Transcriptome, transcriptomics

8. Metagenomics, epigenomics, immunoproteomics, metabolomics, interactomics, metallomics, metalloproteomics, phenomics, nutrigenomics, pharmacogenomics, toxicogenomics, ecogenomics, microbiomics, herbomics, etc.

9. OBDA
Omics
Big Data Analytics

10. BDA Big Data Analytics Skills: Programming Languages
Statistical and Quantitative Analysis
Data Mining, etc

11. CRISPR

12. CRISPR/Cas Genome or gene editing Gene repair 1987 – 2002 – 2012
“clustered regularly interspaced short palindromic repeats”

13. Precision medicine Personalised medicinePM
Precision medicine Personalised medicine

14. Structure and function Stem cell research & therapy
Individual
Growth/Development
Systems
Differentiation
Organs
Tissues
Regulation
Cells
Structure and function
Stem cell research & therapy

17. Ethical, legal, social, moral, economic, political issues of genetic research
Scientific advances outpace legislation, policy
Privacy & fair use of genetic information: genetic discrimination owing to inappropriate access to, and use of, private genetic information – abuse, job, insurance, who should know
Clinical integration of genetic technologies
Research ethics
Ownership rights, patents

18. Ethical, legal, social, moral, economic, political issues of genetic research
Reproductive rights: eugenics
Genetic enhancement: eugenics
Good health, long life: youth? ageing?
Geriatric society

19. Y
are
oung

20. curious creative
daring
humble
passionate Be

21. Don’t be afraid of failure & asking
“Stay hungry,
Stay foolish”
Don’t be afraid of failure & asking

22.
5 boys and 5 girls (up to 17 years old) will win a medal, a certificate and an iPad

23. Dr. Wu Lien Teh 伍連德 1879 – 21.1.1960 plague fighter
1910, ended the large pneumonic plague pandemic of Manchuria and Mongolia which ultimately claimed 60,000 victims

24. Dr. Wu Lien Teh 伍連德 1879 – 21.1.1960 plague fighter
The first Malayan nominated to receive a Nobel Prize in Physiology or Medicine in 1935

25. Good luck & Thank you!