1. Cyclodextrin-Mediated Hierarchical Self-Assembly and Its Potential in Drug Delivery Applications 
Iurii Antoniuk, Catherine Amiel 
Journal of Pharmaceutical Sciences 
Volume 105, Issue 9, Pages (September 2016)
DOI: /j.xphs
Copyright © 2016 American Pharmacists Association® Terms and Conditions

2. Figure 1 Levels of hierarchical self-assembly of collagen.
Reproduced from Elemans et al.3
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3. Figure 2
Components and formulation principle of the siRNA targeted delivery system CALAA-01. The supramolecular host-guest complexes are first formed between linear βCDP and bifunctionalized Tf-PEG-Ada in the Vial 2; upon mixing with the siRNA (Vial), they hierarchically self-assemble into sterically stabilized targeted nanoparticles.
Adapted from Davis.47
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4. Figure 3
(a) Formulation of CD-PEI nanoparticles by condensation between plasmid DNA and positively charged βCD-grafted PEI; (b) Immobilization of the resulting polyCDplexes onto Ada modifies surface via multivalent inclusion interactions.
Adapted from Park et al.59
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5. Figure 4
(a) Schematic illustration of the polyCDplexe hierarchical self-assembly among pβCD, cationic connector, and DNA; (b) chemical structures of various Ada-connectors; (c) Transmission electron microscopy images illustrating the evolution of plasmid DNA compaction degree as a function of the amount of cationic connector Ada5 associated with prior polyCDplexe formation (pβCD/Ada5/DNA = 20/X/1). The first image (X = 0) represents free pDNA in water.
Adapted from Wintgens et al.62
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6. Figure 5
Formulation of supramolecular gene vectors: (a) rotaxanation of the PCL block of the brPEI-PCL-PEG ternary copolymer by inclusion complexation with α-cyclodextrin; (b) formation of polyplexes via electrostatic association with DNA.
Adapted from Shuai et al.66
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7. Figure 6
(a) Chemical structures of used guest (PPEGMA-co-PHEMA-AD) and host (PHPMAco-PPMA-DOX-CD) polymers with pH-sensitive AD-benzoic imine (cleaved at pH 6.5) and DOX-hydrazone (cleaved at pH 5) links respectively; (b) schematic illustration of the formation of host-guest self-assemblies and their dual pH-responsive rearrangement endolysosomal internalization and drug release.
Adapted from Zan et al.77
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8. Figure 7
Formation of hierarchical core-shell nanoparticles for delivery of doxorubicin with switchable tumor cell triggered targeting and release.
Reproduced from Quan et al.80
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9. Figure 8
Schematic representation of the formation and redox-triggered disassembly of the TPPC6-SS-Ada/PEG-βCD hierarchical micelles for photodynamic therapy.
Adapted from Liu et al.83
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10. Figure 9
Schematic illustration of the proposed mechanism of the hydrophobic self-assembly and competitor-induced disassembly of the βCD/tyrosine-based hierarchical vesicles.
Reproduced from Ma et al.84
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11. Figure 10
Doxorubicin and apoptosis-inducing pDNA co-delivery system obtained via 2-step host-guest mediated hierarchical self-assembly.
Adapted from Fan et al.85
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12. Figure 11
Host-guest mediated bricks and mortar approach for the preparation of size-controlled Au-SNPs.
Reproduced from Wang et al.87
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13. Figure 12
Schematic illustration of the βCD-P-coated nanoMOF host-guest PEGylation strategy.
Adapted from Agostoni et al.95
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14. Figure 13
Schematic illustration of the 2-step hierarchical CD-PPRTX gel formation mechanism: (a) hydrophobically driven inclusion of high molecular weight PEG chains into αCD; (b) hydrogen bonding between the threaded αCD microcrystalline domains leading to gelation.
Adapted from Liu et al.107
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15. Figure 14
Schematic illustration of the inclusion-driven formation of αCD/PEG-PHB-PEG polypseudorotaxane (a) and αCD/PEG-PHB-PEG-based doubly cross-linked hydrogel (b).
Adapted from Li et al.109
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16. Figure 15
Schematic illustration of the preparation of αCD/PEG PPRTX hierarchical hydrogels containing pDNA polyplexes for gene transfection and sustained release.
Reproduced from Li et al.116
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17. Figure 16
Illustration of the star-star supramolecular complex formation via βCD/Ada inclusion complexation, followed by its temperature-triggered hierarchical hydrogelation.
Reproduced from Zhang et al.123
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18. Figure 17
Schematic illustration of the formation and temperature- or competitor-triggered dissociation of QD-containing hierarchical hydrogels made of HIC.
Reproduced from Liu et al.99
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19. Figure 18
Schematic illustration of the UV/Vis irradiation and competitor binding responsiveness of the bacteriophage M13-βCD/HA-Azo hierarchical hydrogel.
Reproduced from Chen et al.128
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20. Figure 19
Schematic illustration of the formation of hierarchical chemically responsive hydrogels containing amphiphilic βCD supramolecular vesicles as cross-linking points.
Adapted from Himmelein et al.101
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