1. Clinical Translational Science Award Applications & Family Medicine
Bernard Ewigman, MD
Freddy Chen, MD
Lloyd Michener, MD
October 17, 2006

2. Clinical Translational Science Awards (CTSA)
Introduction to CTSA & Univ of Chicago Experience -- Bernard Ewigman
NAPCRG & ADFM (Department Chairs) Surveys -- Freddy Chen
Duke University Experience, General Themes & Challenges -- Lloyd Michener
Discussion -- All participants

3. Clinical Translational Science Awards (CTSA)
$100 million awarded to 12 Academic Health Centers (AHCs) plus 52 Planning Grants
By 2012, $500 million awarded to 60 AHCs
Purpose: Part of the National Institutes of Health (NIH) Roadmap Plan

4. CTSA Purpose
“First systematic change to clinical research in 50 years.”
“Discovery engines..applying medical advances to real world practice.”
“…new approaches to reaching underserved populations.”
“….to insure that medical advances are reaching those who need them.”
NIH Director Elias A. Zerhouni, M.D.
October 3, 2006

5. CTSA Expectations Create new Institute, Center or Department
Create new discipline of “Clinical Translational Science”.
Multi-disciplinary
Folds in the General Clinical Research Centers and K-12 (post-graduate training) awards

6. CTSA Funding $4 million/per year x 5 years
$6 million/per year x 5 years if Pediatrics and Community Engagement is included.
Indirect costs come out of the total
K-12 training costs come out of the total
Reminder (~$2 million) allocated to 10 required components
U-54 mechanism—all funding for infrastructure development

7. University of Chicago CTSA
Proposed Institute for Translational Science
Four Divisions: Core Resources, Clinical Trials, Training and Community Translational Science Divisions (CTSD)
Ewigman (Family Medicine)– Director of CTSD
Hickner – (Co-Director of Practice Based Research Programs – within CTSD)

8. Practice Based Research Networks
Advocate Health Systems
2,700 physicians
5 community based hospitals
2 family medicine residency programs
New network, but strong track record
ACCESS Community Health Networks
Largest CHC in the US
48 health centers
1 family medicine residency program
4 active, 2 planned family medicine research studies

9. Univ of Chicago Review Score = 197 (possible range 100 to 500)
Outstanding (2 sections)
Excellent (10 sections)
Very Good to Excellent (4 sections)
Including “Community Engagement”
Very Good (1 section)
“Training”

10. Univ of Chicago Review General criticisms:
Not well integrated across components
Did not define obstacles well
Lack epidemiology and clinical epidemiology
Lack of training of community participants
Lack of engagement of the community in decision making