1. S3 Fig
Inactivity of inhibitors of reverse transcriptase and integrase
NVP Nevirapine – NNRTI, non-nucleotide reverse transcriptase inhibitor
AZT Azidothymidine – NRTI, nucleoside analogue reverse transcriptase inhibitor A B
24 h
48 h
240
220
200
180
160
140
Relative copy number
of provirus
Positive-strand HIV-1 DNA
(copies/1 ng genomic DNA)
120
100 80 60 40 20
♯ ♯ ♯ ♯ ♯ ♯ ♯ ♯2
- NVP
+ NVP
- AZT
+ AZT
- AZT
+ AZT
118-D-24 Integrase inhibitor; azido-, diketo acid derivative – blocks DNA strand transfer C D
Relative copy number of provirus
- 118D24
+ 118D24 E
♯ ♯ ♯ ♯2 2 4 6 8 10 12 14 16
p24, ng/ml
AZT, 3µM
NL4-3(VSVG)
NVP, 10µM + _
Relative copy number of provirus
- NVP
+ NVP