1. (1 mmol), aniline (1 mmol) or indole (1 mmol) and kojic acid (1 mmol)
Table 1. Optimization of the reaction conditions for synthesis of 2-phenyl amino kojic acid using reaction of aldehydes
(1 mmol), aniline (1 mmol) or indole (1 mmol) and kojic acid (1 mmol)
Entry
Catalyst, 5 mg
Aniline / (Indole)
Solvent
Time
Yields, % 1
Catalyst-Free
aniline or (indole)
Solvent-Free
24h 2
Fe3O4 NP
aniline
24 h 21 3
MNPs-MSA
65 min 97 4
CH3CN 75 5
CH2Cl2 52 6
EtOH 35 7
(indole) 25 8
40 min 96 9 77 10 47 11 66
Mehdi Forouzani et al. Synthesis, Characterization and Catalytic Properties of Magnetic Nano Supported Molybdat
Sulfuric Acid NPs) in Base Catalyzed Synthesized of 2-Substituted aryl(amino) and (indolyl) Kojic Acid
Derivatives under Solvent-free Conditions. World Journal of Organic Chemistry, 2016, Vol. 4, No. 1, 1-7. doi: /
wjoc-4-1-1
© The Author(s) Published by Science and Education Publishing.