1. The role of the inflammasome in patients with autoinflammatory diseases 
Hal M. Hoffman, MD, Lori Broderick, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 138, Issue 1, Pages 3-14 (July 2016)
DOI: /j.jaci
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
General inflammasome structure and function. Inflammasomes are multimeric protein complexes consisting of a sensor, an effector, and usually an adaptor protein. Oligomerization is triggered by danger-associated molecular patterns (DAMPs) or PAMPs, resulting in effector activation and leading to maturation of procytokines and pyroptosis, a form of inflammatory cell death.
Journal of Allergy and Clinical Immunology  , 3-14DOI: ( /j.jaci )
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
Specific inflammasome structure and triggers. Sensor proteins known to form inflammasomes include NLRP1, NLRP3, NLRC4, AIM2, and pyrin. Although most inflammasomes are triggered by specific pathogen-associated molecules, the NLRP3 inflammasome is activated by a variety of danger signals, as well as some pathogens. Inflammasome component proteins consist of shared domains that mediate protein-protein interactions, including pyrin domains (PYD) and caspase activation and recruitment domains (CARD). Domains observed in some component proteins include leucine-rich repeat (LRR) domains, NACHT, BIR, HIN, Bbox, B30.2, and FIIND domains. Caspase-1 (CASP1) contains p20 and p10 subunits that are cleaved when activated.
Journal of Allergy and Clinical Immunology  , 3-14DOI: ( /j.jaci )
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Fig 3
Inhibitors of the IL-1 pathway. There are 3 approved drugs that block IL-1–mediated inflammation by preventing IL-1β from binding to the IL-1 receptor. Anakinra is a recombinant form of the natural IL-1 inhibitor IL-1RA, which binds to the IL-1 receptor. Rilonacept is a fusion protein, and canakinumab is an mAb that binds IL-1β.
Journal of Allergy and Clinical Immunology  , 3-14DOI: ( /j.jaci )
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5. Fig 4
Targeting the inflammasome pathway. Treatment strategies for blocking the inflammasome pathway include targeting upstream activators of the inflammasome or specific inflammasome component proteins. Inhibitors of caspase-1 activation or IL-1 receptor signaling are additional therapeutic approaches. cAMP, Cyclic AMP; ROS, reactive oxygen species.
Journal of Allergy and Clinical Immunology  , 3-14DOI: ( /j.jaci )
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions