1. Severe coronary artery stenoses and reduced coronary flow velocity reserve in atherosclerotic mouse model 
Antti Saraste, Ville Kytö, Iina Laitinen, Markku Saraste, Pia Leppänen, Seppo Ylä-Herttuala, Pekka Saukko, Jaakko Hartiala, Juhani Knuuti 
Atherosclerosis 
Volume 200, Issue 1, Pages (September 2008)
DOI: /j.atherosclerosis
Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

2. Fig. 1
Representative histology of the proximal LCA in a LDLR/ApoB48 double knockout mouse (a and b). Note the atherosclerotic plaque extending from the aorta (Ao) causing >90% of cross-sectional luminal narrowing. Middle LCA did not show obstruction (c). Typical colour Doppler view of the proximal and middle (arrow) LCA (d) and flow velocity profiles obtained with pulsed wave Doppler from the mid-LCA at rest (e) and during adenosine infusion (f). Note that peak flow velocity increases from 0.3m/s at rest to 0.7m/s during adenosine infusion in this mouse.
Atherosclerosis  , 89-94DOI: ( /j.atherosclerosis )
Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

3. Fig. 2
There was a reduction in mean CFVR in atherosclerotic LDLR/ApoB48 double knockout mice (DKO) when compared with control mice. Atherosclerotic mice that had severe proximal stenosis of the LCA (≥70%) had consistently lower CFVR than mice with mild stenosis (<70%). *p=0.02, **p=
Atherosclerosis  , 89-94DOI: ( /j.atherosclerosis )
Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

4. Fig. 3
There was a significant inverse correlation between CFVR and maximal luminal narrowing in atherosclerotic mice.
Atherosclerosis  , 89-94DOI: ( /j.atherosclerosis )
Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions