1. Serum Albumin Iodinated(DB00064) Approved Drug
Chemical Formula: C2936H4624N786O889S41
Molecular Weight:
A diagnostic radiopharmaceutical containing iodinated I 131 albumin for intravenous imaging. Following intravenous injection, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly (2 days). Indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times
Indication/Usage
For determination of total blood and plasma volumes
Pharmacodynamics
Regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism Of Action
Serum albumin acts as a high molecular weight, very soluble osmolyte

2. Experimental Properties
Category
Diagnostic Agents
Affected Organism
Humans and other mammals
Sequence
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQGLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVGSKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDCLSVFLNQLCVLHEKTPVSDRVTKCCTESLVNGRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
Experimental Properties
Melting Point-62 °C
Hydrophobicity: 0.395
Isoelectric Point: 5.67
Targets
Apolipoprotein E,Serum amyloid A-1 protein,Protein AMBP
Marketed Brands
Megatope: IsoTex Diagnostics
Jeantope: IsoTex Diagnostics
Volumex: IsoTex Diagnostics

3. Megatope Formulation Used/Prescribed for Dosage Contraindications
Megatope (Iodinated I 131 Albumin Injection) is a diagonostic radiopharmaceutical containing iodinated I 131 albumin. Megatope was prepared from blood that was nonreactive when tested for hepatitis. Megatope (Iodinated I 131 Albumin Injection) may be colorless to very pale yellow solutions for Intravenous administration
Formulation
Each mL of sterile, nonpyrogenic, aqueous, colorless to very pale yellow solution provides approximate 10 mg, protein (albumin human), 16 mg dibasic sodium phosphate, 1.6 mg monobasic, sodium phosphate, not more than 0.4 guanidine hydrochloride, sodium chloride, for isotonicity, and 9 mg benzyl alcohol as a preservative.
Used/Prescribed for
Megatope (Iodinated I 131 Albumin Injection) is indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times, and in protein turnover studies, heart and great vessel,dilineation, localization of the placenta, and localization of celebral neospasms
Dosage
The total dosage administered in any one week should not exceed 200 microcuries
Contraindications
None Known
Side-effects
Although the immunological properties of albumin human are believed to be virtually unaltered by the iodination process, there is a theoretical possibility that allergic reactions may occur in patients receiving additional doses a number of weeks after an initial dose
References

4. Jeantope Formulation Used/Prescribed for Dosage Contraindications
Jeanotope I-125 was prepared from the blood that was non-reactive when tested for hepatitis B surface antigen (HBsAg) and HIV antibody. Jeanatope (Iodinated Albumin Injection) is a sterile, nonpyrogenic, aqueos solution administered as a intavenous injection
Formulation
Each milliliter provides approximately 10 mg protein (normal human serum albumin), 1.6 mg sodium phosphate, 16 mg sodium biphosphate, not more than 0.4 mg guanidine hydrochloride, sodium chloride for isotonicity, and 9 mg benzyl alcohol as a preservative. The stabilizer aceryltryptophanate and sodium caprylate have a concentration of less, than M.
Used/Prescribed for
Jeanotope I-125 is indicated for use in the determination of total blood and plasma volume.
Dosage
When a procedure such as a blood volume determination is to be repeated, the total dosage administered in any one week should not exceed 7.4 megabecquerels, (200 microcuries)
Contraindications
At present there are no known contraindications to the use of this preparation
Side-effects
Although the immunological properties of serum albumin are believed to be virtually unaltered by the iodinated process, there is a theoretical possibility that allergic reactions may occur in patients receiving additional doses a number of weeks after an initial dose
References
44d870ee6547

5. Volumex Formulation Used/Prescribed for Dosage Contraindications
Jeanotope I-125 was prepared from the blood that was non-reactive when tested for hepatitis B surface antigen (HBsAg) and HIV antibody. Jeanatope (Iodinated Albumin Injection) is a sterile, nonpyrogenic, aqueos solution administered as a intavenous injection
Formulation
Each milliliter provides approximately 10 mg protein (normal human serum albumin), 1.6 mg sodium phosphate, 16 mg sodium biphosphate, not more than 0.4 mg guanidine hydrochloride, sodium chloride for isotonicity, and 9 mg benzyl alcohol as a preservative. The stabilizer aceryltryptophanate and sodium caprylate have a concentration of less, than M.
Used/Prescribed for
Jeanotope I-125 is indicated for use in the determination of total blood and plasma volume.
Dosage
When a procedure such as a blood volume determination is to be repeated, the total dosage administered in any one week should not exceed 200 microcuries
Contraindications
None Known.
Side-effects
Although the immunological properties of serum albumin are believed to be virtually unaltered by the iodinated process, there is a theoretical possibility that allergic reactions may occur in patients receiving additional doses a number of weeks after an initial dose
References