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Volume 44, Issue 1, Pages (February 2017)

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Presentation on theme: "Volume 44, Issue 1, Pages (February 2017)"— Presentation transcript:

1 Volume 44, Issue 1, Pages 13-23 (February 2017)
Prevention of 5-fluorouracil-induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: Assessment of a multiparametric approach  Michele Boisdron-Celle, Olivier Capitain, Roger Faroux, Christophe Borg, Jean Philippe Metges, Marie Pierre Galais, Mehdi Kaassis, Jaafar Bennouna, Karine Bouhier-Leporrier, Eric Francois, Isabelle Baumgaertner, Véronique Guerin-Meyer, Oana Cojocarasu, Celia Roemer-Becuwe, Claire Stampfli, Ludovic Rosenfeld, Thierry Lecompte, Virginie Berger, Alain Morel, Erick Gamelin  Seminars in Oncology  Volume 44, Issue 1, Pages (February 2017) DOI: /j.seminoncol Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Fig. 1 Metabolic pathways of 5-fluorouracil.
Seminars in Oncology  , 13-23DOI: ( /j.seminoncol ) Copyright © 2017 Elsevier Inc. Terms and Conditions

3 Fig. 2 Distribution of DPD enzyme activity in a healthy population. Distribution of DPD enzyme activity in the 132 caucasian individuals tested in this study. The distribution differs significantly from Gaussian Normal and has significant positive skew and kurtosis [7]. Seminars in Oncology  , 13-23DOI: ( /j.seminoncol ) Copyright © 2017 Elsevier Inc. Terms and Conditions

4 Fig. 3 Different SNPs in the hot spots of the DPYD gene. In red are shown the SNPs systematically screened in clinical practice. Seminars in Oncology  , 13-23DOI: ( /j.seminoncol ) Copyright © 2017 Elsevier Inc. Terms and Conditions

5 Fig. 4 Study design. Seminars in Oncology  , 13-23DOI: ( /j.seminoncol ) Copyright © 2017 Elsevier Inc. Terms and Conditions

6 Fig. 5 Survival probability of the two populations of patients without grade ≥3 toxic events (arm A: blue, arm B: red). Seminars in Oncology  , 13-23DOI: ( /j.seminoncol ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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