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Includes Studies of Neurological Diseases & Personality

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Presentation on theme: "Includes Studies of Neurological Diseases & Personality"— Presentation transcript:

1 Includes Studies of Neurological Diseases & Personality
Neurogenetics Science of the Effect of the Genetic Code and its Inheritance on the development  & function of the Nervous System and Behaviour Includes Studies of Neurological Diseases & Personality by Timo Pohl

2 Neurological Disorders Neurodegenerative Diseases
Schizophrenia – NOTCH 4                  Zinc Finger Protein 804 A Alzheimer's Disease – APOE,                                        PICALM ADHD – Genes involved in Dopamine Neurotransmission Multiple Sclerosis – DR15, DQ6 Tourette's Syndrome,Autism, Epilepsy, Mental Retardation etc... Parkinson's Disease – LRRK2,                                              PARK2, PARK7 Huntington's Disease - HTT ALS – SOD1,ALS2

3 Methods of Research Statistical Analysis Recombinant DNA
Logarithm of Odds (LOD) - used in combination with pedigrees Quantitative Trait Loci (QTL) - screening for specific gene markers Recombinant DNA Any mutated form of a gene – induced or randomly occuring Forward/backward genetics Pheno-genotype/geno-phenotype Animal Research The role of genes and its interactions in creatures with simple NS & smaller genomes but evolutionary conserved homologous genes Mice, Drosophila, C. elegans, Zebrafish Reverse genetics: Recombinant Gene > Observation Cannot completely model the complexity of the human body Human Research Volunteers with certain coditions & illnesses Sampling of CSF, Blood, Muscle Tissue > Gene Sequencing

4 Behavioral Neurogenetics
Observation of Effect & Interaction of genes on Behaviour & Traits Usually complex polygenic interaction of variants of genes Cross-Species Conservation  - Evolutionary Conserved Genes Higher Cognitive Function -  Dopamine Gene Expr. > Motivation&Learning > Synaptic Plasticity > Faster Response Time Aggression Different Levels of Aggression throughout Animal Kingdom Dependent on Serotonin and its Metabolism Serotonin(5HT), 5HT Receptor, MAO, SERT MAO-A Deficient Dutch Family – displayed over-average aggressive behavior Alcohol Dependency ALDH1B,2 Polymorphism > decreased Alcohol Met. > Predisposition to Alcoholism

5 Current Research Rapidly expanding & growing field since Human Genome Project (HGP) succeeded in decoding the entire Human Genome in 2003 helps identifying, understanding Neurological Disorders Important for classification & possible treatment


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