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Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model  Cüneyt Köksoy, MD, Erpulat Oziş, MD, Atıl Çakmak, MD,

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Presentation on theme: "Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model  Cüneyt Köksoy, MD, Erpulat Oziş, MD, Atıl Çakmak, MD,"— Presentation transcript:

1 Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model 
Cüneyt Köksoy, MD, Erpulat Oziş, MD, Atıl Çakmak, MD, Uğur Yazgan, PhD, Aylin Okcu-Heper, MD, Aslıhan Köksoy, MD, PhD, Ediz Demirpençe, MD, U. Deniz Dinçer, MD, PhD  Journal of Vascular Surgery  Volume 45, Issue 3, Pages (March 2007) DOI: /j.jvs Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 The appearance of gastrocnemius muscles stained with nitroblue tetrazolium dye just before planimetry. A, Viable muscle stained dark, and (B) nonviable muscle remained pale and unstained. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Box plots show the extent of skeletal muscle edema and necrosis determined by the ratio of the wet to dry tissue weight of the gastrocnemius sections. Whiskers show quartile ranges. *P < .05, ‡P < .01, and †P < .001. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Box plots show the levels of malondialdehyde (MDA), glutathione (GSH), and myeloperoxidase (MPO) in the experimental groups. Whiskers show quartile ranges. *P < .05, ‡P < .01. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

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