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Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids Research Article 

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Presentation on theme: "Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids Research Article "— Presentation transcript:

1 Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids Research Article  M. M. Khalil , Y. M. Issa, and M. A. Korany Scholars Report | Volume 2, Issue 1 | 2017 Copyright © Policy

2 Figure 1: The chemical structure of benzydamine hydrochloride.
Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

3 Figure 2: Conductometric titration curves of 1
Figure 2: Conductometric titration curves of 1.0×10-2 mol L-1 Benz against 1.0×10-2 mol L-1 PTA and PMA  Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

4 Figure 3: Calibration graphs for: (a) sensor B and (b) sensor A at optimum membrane composition.
Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

5 Table 1: Effect of the content of ion pairing agents on the performance of the proposed sensors
Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

6 Table 2: Effect of the content of ion pairing agents on the performance of the proposed sensors
Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

7 Table 3: Effect of the plasticizers on Benz responsive sensors.
Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

8 Figure 4: Effect of pH on the performance of sensor A: (a) 1
Figure 4: Effect of pH on the performance of sensor A: (a) 1.0 x 10-3 mol L-1 Benz and (b) 1.0 x10-4 mol L-1 Benz. Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

9 Figure 5: Potential–time plot for the response of sensor B.
Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

10 Table 4: Selectivity coefficient values ( ) for BENZ sensors
Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

11 Table: 5 Determination of Benz in pure form using the proposed sensor
a Mean of three determinations Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

12 Table 6: Determination of Benz in pharmaceutical formulation (TANTUM VERDE) using the proposed sensors a Mean of three determinations Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

13 Table 7: Determination of Benz in biological fluids (plasma and urine).
a Mean of three determinations Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

14 Figure 6: Potentiometric titration curves of (a) 3, (b) 6, (c) 9 and (d) 12 mL of 10-2 mol L-1 Benz using sensor A and 10-2 mol L-1 PTA as titrant  Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

15 Table 8: Statistical comparison between the results of an analysis of a pharmaceutical preparation TANTUM VERDE applying the standard addition and potentiometric titration methods a: Average of four determinations b: Tabulated F-value at 95% confidence level c:Tabulated t-value at 95% confidence level and six degrees of freedom Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright © Policy

16 M. M. Khalil 1*, Y. M. Issa2, and M. A. Korany1
Thank You  Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids M. M. Khalil 1*, Y. M. Issa2, and M. A. Korany1 About the Author * Corresponding Author: Khalil MM 1 Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt 2 Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt *Corresponding Author: Editor: Dr. Alessandra A. Correa Center for Engineering, Modeling and Applied Social Sciences (CECS), Federal University of ABC, (UFABC), , Santo André, SP, Brazil Citation and Copyrights Citation: Khalil MM, Issa YM, and Korany MA. Novel Modified Carbon Paste Sensors for Determination of Benzydamine Hydrochloride in Pharmaceutical Formulations and Biological Fluids. ScholReps 2017 Jan; 2(1). Copyright: © Khalil MM. et al .This is an open access article distributed under the terms of the Creative Commons Attribution 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Received: Nov 2, Accepted: Jan 16, Published: Jan 30, 2017 Funding: None. Subject : Clinical Toxicology Conflict of interest: The authors have read the journal’s policy and declare that there is no conflicts of interests regarding the focus, interest or any of the contents of this work. Funding: None Copyright © Policy

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